Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy

Autor: Joseph Tung-Chieh Chang, Ling Yeung, Din-Li Tsan, Wing-Keen Yap, Shih-Ming Huang, Ju-Wen Yang, Yun-Hsuan Lin, Lung-Chien Chen
Rok vydání: 2020
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
lcsh:R895-920
Lacrimal gland
Disease
Ophthalmologic Surgical Procedures
Eye
lcsh:RC254-282
03 medical and health sciences
Young Adult
0302 clinical medicine
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Stage (cooking)
Radiation Injuries
Lacrimal Gland Carcinoma
Aged
Retrospective Studies
Aged
80 and over
Chemotherapy
Lacrimal Apparatus Diseases
Radiotherapy
business.industry
Orbital tumors
Eye Neoplasms
Research
Cancer
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
Surgery
Radiation therapy
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
030221 ophthalmology & optometry
Female
Radiotherapy
Adjuvant
Lacrimal gland carcinoma
Orbital exenteration
business
Adjuvant
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 15, Iss 1, Pp 1-10 (2020)
ISSN: 1748-717X
Popis: Background The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory outcomes, but evidence is sparse. The aim of the present study was to evaluate outcomes in patients with lacrimal gland cancer treated at two tertiary medical centers. Methods We retrospectively examined data from patients with lacrimal gland cancer who had received eye-preserving surgical treatment followed by adjuvant RT with or without chemotherapy, or (if the tumor was inoperable) needle biopsy with definitive RT with or without chemotherapy. Baseline clinical and pathological characteristics were considered. Outcomes of interest included post-treatment complications, overall survival (OS), locoregional progression-free survival (LPFS), and distant metastasis-free survival (DMFS). Results Eighteen patients were included. Two-year OS, LPFS, and DMFS rates were 69.0, 76.7, and 71.4%, respectively. Patients with early-stage (T1–T2) lacrimal gland cancer had significantly better outcomes than those with advanced-stage disease (T3–T4). Two-year OS, LPFS, and DMFS rates were each 100% in patients with disease stages T1–T2, and 37.5, 50, and 37.5%, respectively, in those with disease stages T3–T4 (P Conclusions Eye-sparing surgery with adjuvant RT can achieve satisfactory results in patients with T1–T2 lacrimal gland carcinoma. Disease stage T3 and above was associated with poor outcomes even with post-operative RT, likely due to distant metastasis. Adding neoadjuvant chemotherapy or adjuvant chemotherapy to current treatment strategies might be a suitable choice for this group of patients.
Databáze: OpenAIRE
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