Effect of an immune-enhancing diet on lymphocyte in head-injured rats: What is the role of arginine?

Autor: Djamel, Hamani, Christine, Charrueau, Marie-José, Butel, Valérie, Besson, Linda, Belabed, Ioannis, Nicolis, Servane, Le Plénier, Catherine, Marchand-Leroux, Catherine, Marchand-Leromp, Jean-Claude, Chaumeil, Luc, Cynober, Christophe, Moinard
Rok vydání: 2007
Předmět:
Zdroj: Intensive Care Medicine. 33:1076-1084
ISSN: 1432-1238
0342-4642
DOI: 10.1007/s00134-007-0624-0
Popis: The benefit of immune-enhancing diets (IEDs) in the intensive care unit remains controversial. Considering their complexity, the role of each component, in particular arginine (Arg), in their properties is largely unknown. The aim of this study was to determine the role of arginine in the immunomodulatory effects of an IED (Crucial®) in head-injured rats. Thirty-four rats were randomized into five groups: AL (ad libitum), HI (head-injured), HI-STD (HI + standard enteral nutrition, EN), HI-STD-Arg (HI + standard EN + Arg in equimolar concentration to Arg in IED), and HI-IED (HI + IED). These isocaloric and isonitrogenous diets were administered over 4 days. After death, the thymus was removed and weighed. The density of CD25, CD4 and CD8 on lymphocytes from blood and from Peyer patches was evaluated. Mesenteric lymph nodes, liver and spleen were cultured for analysis of enterobacterial translocation and dissemination. HI induced an atrophy of the thymus which was not corrected by the standard diet (HI 0.27 ± 0.03, HI-STD 0.35 ± 0.03 vs. AL 0.49 ± 0.02 g; p
Databáze: OpenAIRE
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