Human umbilical cord Wharton's jelly-derived mesenchymal stem cell transplantation could improve diabetic intracavernosal pressure
Autor: | Qi Jiang, Lu Sheng, Wei-Qing Qian, Shu-Jie Xia, Jian-Hong Wu, Dong-Ya Wang |
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Rok vydání: | 2021 |
Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Urology medicine.medical_treatment Basic fibroblast growth factor Mesenchymal Stem Cell Transplantation Umbilical cord Diabetes Mellitus Experimental Umbilical Cord chemistry.chemical_compound Erectile Dysfunction Enos Internal medicine Wharton's jelly medicine Animals Humans Wharton Jelly biology business.industry Growth factor Mesenchymal stem cell Cell Differentiation General Medicine biology.organism_classification Rats Transplantation Vascular endothelial growth factor Endocrinology medicine.anatomical_structure chemistry business |
Zdroj: | Asian journal of andrology. 24(2) |
ISSN: | 1745-7262 |
Popis: | Mesenchymal stem cells (MSCs) secrete various cytokines with angiogenic and neuroprotective effects. This study aimed to assess the effects of human umbilical cord Wharton's jelly-derived MSCs (hWJ-MSCs) on diabetes-related intracavernosal pressure (ICP) impairment in rats. hWJ-MSCs were isolated from human umbilical cord Wharton's jelly and transplanted into the corpus cavernosum of streptozotocin (STZ)-induced diabetic rats by unilateral injection. The erectile function was evaluated at 4 weeks, as well as the expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), endothelial nitric oxide synthase (eNOS), and insulin-like growth factor 1 (IGF1). STZ-induced diabetic rats showed impaired ICP, which was significantly improved by hWJ-MSC treatment. VEGF, eNOS, IGF1, and bFGF expression levels were higher in hWJ-MSC injection sites than those in control ones in STZ-induced diabetic rats. These results suggest that hWJ-MSC transplantation might improve diabetic erectile dysfunction through increased production of paracrine growth factors, highlighting a novel potential therapeutic option for erectile dysfunction. |
Databáze: | OpenAIRE |
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