CT-guided thrombolytic treatment of patients with wake-up strokes
| Autor: | Itzhak Kimiagar, Angela Kriboushay, Rina Aroesty, Zoya Haitov, Aviv Gour, Eduard Ilgiyaev, Alex Blatt, Carmel Armon, Samuel Bar-Hayim, Evelina Shevtzov, Sarah Bhonkar, Avigail Bartal, Fikri Khiri, Jochay Wainstein, Ronen Levite, Sigal Tal, Gilad Kenan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Thrombolytic treatment Efficacy medicine.medical_treatment Subgroup analysis Outcomes lcsh:RC346-429 Brain ct 03 medical and health sciences 0302 clinical medicine Chart review medicine 030212 general & internal medicine Stroke lcsh:Neurology. Diseases of the nervous system business.industry Thrombolysis medicine.disease Parallel cohorts Wake-up strokes Neurology Baseline characteristics Observational study Original Article Radiology Safety business 030217 neurology & neurosurgery |
| Zdroj: | eNeurologicalSci, Vol 14, Iss, Pp 91-97 (2019) eNeurologicalSci |
| ISSN: | 2405-6502 |
| Popis: | Background Observational studies of thrombolysis outcomes in wake-up acute ischemic stroke patients selected based on non-contrast brain CT criteria suggested that treated patients did as well as or better than those not treated, after adjustment for baseline characteristics. We began offering thrombolytic treatment (IVTPA) to patients presenting with wake-up strokes and normal non-contrast brain CTs, who could be treated within 4.5 h of being found. Design/methods A retrospective chart review was performed in patients presenting with AIS between November 2014 and December 2017 who received IVTPA. A planned subgroup analysis compared patients with wake-up strokes and normal non-contrast brain CTs to patients with witnessed stroke treated within 4.5 h of being found, or of witnessed onset, respectively. Results Three hundred and six patients were treated, 279 with witnessed-onset and 27 with wake-up strokes. The latter were not candidates for endovascular intervention. Efficacy and safety were similar in both groups. Discharges home, respectively, were 143(53%) and 13(48%); facility discharges were 112(40.1%) and 11(40.7%) and in-hospital mortality was 19 (6.8%) and 3 (11%). Treatment-related symptomatic bleeds were: 5(1.8%) and 1 (3.7%), respectively. Conclusions The findings affirm, in a new clinical series reflecting routine practice, that it is safe to treat with IVTPA patients with wake-up strokes and a normal brain CT scan, who are not candidates for endovascular intervention. We hypothesize, that when the non-contrast brain CT scan is normal, it may be safe to extend beyond 4.5 h the IVTPA treatment eligibility window in similar patients with witnessed-onset stroke. Highlights • A new patient series reflecting routine stroke care at a university hospital • IVTPA treatment if |
| Databáze: | OpenAIRE |
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