Helicobacter Pylori Interacts with Serum Vitamin D to Influence Hypertension
| Autor: | Ali Salami, Elie Salem-Sokhn, Said El Shamieh, Mirna Fawaz, Ali H. Eid |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Serum vitamin medicine.medical_specialty Helicobacter pylori biology business.industry Confounding Anthropometry biology.organism_classification medicine.disease Gastroenterology vitamin D deficiency Helicobacter Infections Multivariate logistic regression model Cross-Sectional Studies Internal medicine Hypertension Pediatrics Perinatology and Child Health medicine Vitamin D and neurology Humans Vitamin D business Genetic association |
| Zdroj: | Current Aging Science. 14:26-31 |
| ISSN: | 1874-6098 |
| Popis: | Background and objective: Hypertension is a multifactorial disease where numerous constitutive, genetic, and environmental factors interplay. Among the constitutive factors, age is a major determent continuously reported to be associated with a significant increase in the prevalence of hypertension. In addition to age, Helicobacter pylori (H. pylori) infection was also shown to be associated. On the other hand, Vitamin D (Vit D) plays an important role in the development of hypertension. In the current study, it was investigated whether H. pylori interacts with Vit D levels to influence hypertension. Methods: This cross-sectional study was conducted on seven hundred and eighty-two “a priori” healthy individuals equally divided according to hypertension status. To study the association between Vit D, H. pylori, and hypertension, a multivariate logistic regression model was used while correcting for different confounding factors. Power analysis was also performed Results: Approximately half of the participants were hypertensive and had Vit D insufficiency and they were also matched for age. Using a multiple logistic regression model, the results showed an inversely proportionate association between H. pylori infection and the risk of hypertension (OR=0.38, P Conclusion: H. pylori infection and Vit D deficiency could predict hypertension. The odds of hypertension development were double when the participants were negative for H. pylori infection and had vitamin D deficiency. |
| Databáze: | OpenAIRE |
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