Antiemetic effects of baclofen in a shrew model of postoperative nausea and vomiting: Whole-transcriptome analysis in the nucleus of the solitary tract

Autor:	Daisuke Konno, Shigekazu Sugino, Tomoko F Shibata, Kazuharu Misawa, Yuka Imamura‐Kawasawa, Jun Suzuki, Kanta Kido, Masao Nagasaki, Masanori Yamauchi
Rok vydání:	2022
Předmět:	Pharmacology Baclofen Vomiting Gene Expression Profiling Shrews Psychiatry and Mental health Physiology (medical) Postoperative Nausea and Vomiting Solitary Nucleus Animals Antiemetics Pharmacology (medical) Female Emetics
Zdroj:	CNS neurosciencetherapeutics. 28(6)
ISSN:	1755-5949
Popis:	The molecular genetic mechanisms underlying postoperative nausea and vomiting (PONV) in the brain have not been fully elucidated. This study aimed to determine the changes in whole transcriptome in the nucleus of the solitary tract (NTS) in an animal model of PONV, to screen a drug candidate and to elucidate the molecular genetic mechanisms of PONV development.Twenty-one female musk shrews were assigned into three groups: the Surgery group (shrew PONV model, n = 9), the Sham group (n = 6), and the Naïve group (n = 6). In behavioral studies, the main outcome was the number of emetic episodes. In genetic experiments, changes in the transcriptome in the NTS were measured. In a separate study, 12 shrews were used to verify the candidate mechanism underlying PONV.A median of six emetic episodes occurred in both the Sham and Surgery groups. Whole-transcriptome analysis indicated the inhibition of the GABAOur findings suggest that the GABA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a15a60ff04b9b979dc171ef07ec43f https://pubmed.ncbi.nlm.nih.gov/35238164 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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