Dynamics of neovascularization in normal tissue
| Autor: | Shu Chien, Geert W. Schmid-Schoenbein, Rakesh K. Jain, David F. Zawicki |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Growth kinetics
Normal tissue Cubic Millimeter Models Biological Biochemistry Skin Window Technique Neovascularization Vessel density medicine Animals Platelet Blood Volume Chemistry Microcirculation Dynamics (mechanics) Ear Cell Biology Anatomy CELL DEBRIS Kinetics Blood Vessels Rabbits medicine.symptom Cardiology and Cardiovascular Medicine Mathematics Biomedical engineering |
| Zdroj: | Microvascular Research. 21:27-47 |
| ISSN: | 0026-2862 |
| Popis: | Neovascularization of normal tissue was investigated by observing tissue grown in a transparent rabbit ear chamber. Stereological principles, applied to photomicrographs of the tissue, quantified vascular characteristics such as surface area, volume, and length per cubic millimeter of tissue. Mathematical models were developed to simulate growth of the microvasculature. The model developed here possesses, at least from a qualitative point of view, two important properties of observable growth kinetics: cell debris, mostly dead red blood cells and platelets, is required for the neovascularization to begin, and vessel density exhibits a maximum before reaching the steady-state value. |
| Databáze: | OpenAIRE |
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