Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas
| Autor: | Cassandra C. Skinner, Zelia M. Correa, James J. Augsburger, Bret D. Augsburger |
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| Rok vydání: | 2017 |
| Předmět: |
Choroidal melanoma
Adult Male Uveal Neoplasms Adolescent Separation (statistics) Intraocular melanoma Kaplan-Meier Estimate 03 medical and health sciences Young Adult 0302 clinical medicine Humans Routine clinical practice Melanoma Mathematics Aged Neoplasm Staging Aged 80 and over Tumor size business.industry Middle Aged Prognosis Log-rank test 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Female Ultrasonography business Nuclear medicine |
| Zdroj: | Investigative ophthalmologyvisual science. 58(9) |
| ISSN: | 1552-5783 |
| Popis: | Purpose Determine which posterior uveal melanoma (PUM) size classification with three categories has the best prognostic discrimination. Methods Single-institution study of 424 consecutive patients with PUM. The tumor's largest basal diameter (LBD), smallest basal diameter (SBD), and thickness (TH) were estimated by fundus mapping and ultrasonography. Tumors were assigned to "small," "medium," or "large" size categories defined by 11 different classifications (Linear LBD, Rectangular LBD × TH, Cubic LBD × SBD × TH, Warren Original, Warren Modified, Augsburger, COMS Original, COMS Revised, TNM 2002, and modified TNM 2010 classification [a,b]). Prognostic significance of classifications was evaluated by Kaplan-Meier event curves with computation of log rank test for trend statistic. Results In six classification systems (Warren Original, Warren Modified, COMS Revised, TNM 2002, TNM 2010a, TNM 2010b) >50% of tumors fell within one subgroup. In the Warren Original classification |
| Databáze: | OpenAIRE |
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