Immune Response to Sheep Red Blood Cells in Mice Pretreated with Mycobacterial Fractions
| Autor: | E. Yarkoni, E. Lederer, I. Flechner, E. Vilkas, S. Morecki, A. Bekierkunst |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Erythrocytes
Time Factors medicine.medical_treatment Microgram Freund's Adjuvant Immunology chemical and pharmacologic phenomena complex mixtures Microbiology Mice Immune system Antigen Immunity Animals Medicine Antigens Bacterial Immunity Cellular Mycobacterium Infections Sheep Cord factor biology business.industry Hemagglutination Tests Mycobacterium bovis Antibodies Anti-Idiotypic Infectious Diseases Waxes Antibody Formation biology.protein Pathogenic Mechanisms Ecology and Epidemiology Parasitology Rabbits Lymph Glycolipids Antibody business Adjuvant |
| Zdroj: | Infection and Immunity. 4:256-263 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.4.3.256-263.1971 |
| Popis: | Ten micrograms of trehalose-6,6′ -dimycolate (cord factor) injected into the footpads of mice increased the antibody response to sheep red blood cells (SRBC) subsequently injected into the same sites. There is a relationship between the antibody response and the cellular reaction induced locally and in the draining lymph nodes by cord factor, as judged by a much weaker response when antigen is injected into the contralateral footpads. The time intervals between injection of cord factor and antigen were from 5 to 20 days. A similar increased antibody response to SRBC was evident after preliminary administration of Freund's complete adjuvant or living BCG bacilli into the footpads. There was no increased antibody response in mice pretreated with living BCG or Freund's adjuvant to SRBC injected into the contralateral footpads. Administration of wax D from human strains Peurois and Test was without any effect. Administration of SRBC emulsified in incomplete Freund's adjuvant containing 5 μg of cord factor induced a very strong antibody response in the mice as compared to that after injection of the same amount of antigen in incomplete Freund's adjuvant containing wax D or mycobacteria. The results are discussed. |
| Databáze: | OpenAIRE |
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