Antinociceptive and anti-inflammatory activities of the lectin from Marine Red Alga Solieria filiformis
| Autor: | Natássia Albuquerque Ribeiro, Norma Maria Barros Benevides, Mirna Marques Bezerra, Ticiana Monteiro Abreu, Ilka M. Vasconcelos, Hellíada Vasconcelos Chaves, Erika Freitas Mota, Roberta Jeane Bezerra Jorge, Helena Serra Azul Monteiro |
|---|---|
| Jazyk: | portugalština |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.drug_class Pharmaceutical Science Peritonitis Inflammation Pharmacology Anti-inflammatory Analytical Chemistry Mice 03 medical and health sciences chemistry.chemical_compound Lectins Drug Discovery medicine Animals Rats Wistar Plant Proteins Analgesics biology Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Lectin medicine.disease Rats Carrageenan 030104 developmental biology Dextran Complementary and alternative medicine chemistry Rhodophyta Toxicity Immunology biology.protein Molecular Medicine Female medicine.symptom Licking |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Lectins are proteins that bind to specific mono- or oligosaccharides. This study aimed to evaluate the antinociceptive and anti-inflammatory effects of the lectin from the red marine alga Solieria filiformis. The animals (n = 6) were pretreated with S. filiformis lectin 30 min before they were given the nociceptive or inflammatory stimulus. The antinociceptive activity was evaluated in Swiss mice using the abdominal writhing, formalin, and hot plate tests. The anti-inflammatory properties were evaluated in Wistar rats using carrageenan-induced peritonitis and paw edema induced by different phlogistic agents. The S. filiformis lectin toxicity was assayed through its application in mice (7 days). S. filiformis lectin significantly reduced the number of abdominal writhings and reduced the paw licking time in the second phase of the formalin test (p 0.05), but it did not prolong the reaction time in the hot plate test (p 0.05). Furthermore, S. filiformis lectin reduced neutrophil migration in a peritonitis model and reduced paw edema induced by carrageenan, dextran, and serotonin (p 0.05). Additionally, the administration of S. filiformis lectin resulted in no signs of systemic damage. Thus, S. filiformis lectin appears to have important antinociceptive and anti-inflammatory activities and could represent a potential therapeutic agent for future studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|