Protonation State of Dopamine Neurotransmitter at the Aqueous Interface: Vibrational Sum Frequency Generation Spectroscopy Study

Autor:	Biswajit Biswas, Prashant Chandra Singh
Rok vydání:	2022
Předmět:	Neurotransmitter Agents Surface Properties Dopamine Spectrum Analysis Electrochemistry Water General Materials Science Surfaces and Interfaces Condensed Matter Physics Spectroscopy
Zdroj:	Langmuir. 38:1380-1385
ISSN:	1520-5827 0743-7463
DOI:	10.1021/acs.langmuir.1c02505
Popis:	Dopamine is an important amine-based chemical neurotransmitter whose protonated state plays a crucial role in the recognition process. Understanding the structure and protonated state of dopamine at the aqueous interface is desired as the diffusion as well as binding of dopamine with the receptors take place frequently in the aqueous interface region. Vibrational sum frequency generation (VSFG) study of the OH stretch of water at the air/water interface in the presence of dopamine is performed and compared with its analog, phenylethylamine, and catechol. The VSFG data suggest that, unlike the bulk case, the population of the deprotonated amine group of dopamine is higher at the aqueous interface. This study suggests that the structure of dopamine at the aqueous interface is different from the bulk which may be useful in understanding the recognition process of dopamine in the interfacial region.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3799aad4155bbecd21d0ea32bd81b1ae https://doi.org/10.1021/acs.langmuir.1c02505 Zobrazit plný text záznamu