Cerebral neurogenesis is induced by intranasal administration of growth factors
| Autor: | David A. Greenberg, Jocelyn Childs, Anna Logvinova, Xiao Ou Mao, Kunlin Jin, Lin Xie, Yunjuan Sun |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Central nervous system Subventricular zone Stimulation Fibroblast growth factor Mice chemistry.chemical_compound Internal medicine medicine Animals Growth Substances Administration Intranasal Epidermal Growth Factor biology business.industry Growth factor Neurogenesis Brain Doublecortin medicine.anatomical_structure Endocrinology Neurology chemistry biology.protein Intercellular Signaling Peptides and Proteins Fibroblast Growth Factor 2 Neurology (clinical) business Cell Division Bromodeoxyuridine Heparin-binding EGF-like Growth Factor |
| Zdroj: | Annals of Neurology. 53:405-409 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.10506 |
| Popis: | Neurogenesis persists in the adult brain, where it may contribute to repair and recovery after injury, but the lack of methods for noninvasive stimulation of cerebral neurogenesis limits its potential for clinical application. We report that intranasal administration of either fibroblast growth factor–2 or heparin-binding epidermal growth factor–like growth factor increases neurogenesis, measured by the incorporation of bromodeoxyuridine into cells that express the early neuronal marker protein doublecortin in the subventricular zone of mouse brain. These findings indicate that intranasal growth factors may have potential as neurogenesis-promoting therapeutic agents. Ann Neurol 2003;53:405–409 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text