Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity
| Autor: | Malgorzata Wygrecka, Charles W. Frevert, Jessica Felgenhauer, Madalina V. Nastase, Liliana Schaefer |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Histology Inflammasomes Receptor for Advanced Glycation End Products Reviews Inflammation Biology Proinflammatory cytokine 03 medical and health sciences Transforming Growth Factor beta medicine Alarmins Animals Humans Receptor Innate immune system Toll-Like Receptors Pattern recognition receptor Inflammasome Acquired immune system Immunity Innate Cell biology Extracellular Matrix 030104 developmental biology Anatomy Signal transduction medicine.symptom medicine.drug Signal Transduction |
| Zdroj: | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 66(4) |
| ISSN: | 1551-5044 |
| Popis: | It is evident that components of the extracellular matrix (ECM) act as danger-associated molecular patterns (DAMPs) through direct interactions with pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and inflammasomes. Through these interactions, ECM-derived DAMPs autonomously trigger sterile inflammation or prolong pathogen-induced responses through the production of proinflammatory mediators and the recruitment of leukocytes to sites of injury and infection. Recent research, however, suggests that ECM-derived DAMPs are additionally involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity. Thus, in this review, we discuss the current knowledge of the interplay between ECM-derived DAMPs and the innate immune signaling pathways that are activated to provide temporal control of innate immunity. |
| Databáze: | OpenAIRE |
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