DNA replication stress and cancer: cause or cure?
| Autor: | Elaine M. Taylor, Howard D. Lindsay |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Genome instability DNA Replication Cancer Research DNA Repair Ataxia Telangiectasia Mutated Proteins Biology Bioinformatics Genomic Instability 03 medical and health sciences Neoplasms Animals Humans DNA Breaks Double-Stranded Cancer Cause Replication stress DNA replication General Medicine Oncogenes Cancer treatment 030104 developmental biology Cell Transformation Neoplastic Oncology Mutation Disease Progression DNA Damage Signal Transduction |
| Zdroj: | Future oncology (London, England). 12(2) |
| ISSN: | 1744-8301 |
| Popis: | There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that these cancers rely heavily on replication stress response pathways for their continued proliferation. This raises the possibility that the pathways that ordinarily protect cells from the accumulation of cancer-causing mutations may actually prove to be effective therapeutic targets for a wide range of malignancies. In this review, we explore the mechanisms by which sustained proliferation can lead to replication stress and genome instability, and discuss how the pattern of mutations observed in human cancers is supportive of this oncogene-induced replication stress model. Finally, we go on to consider the implications of replication stress both as a prognostic indicator and, more encouragingly, as a potential target in cancer treatment. |
| Databáze: | OpenAIRE |
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