Olanzapine Induces Insulin Resistance
| Autor: | Markus Laimer, W. Wolfgang Fleischhacker, Martina Hummer, Georg Kemmler, Elisabeth M. Weiss, Josef R. Patsch, Christoph Ebenbichler, Alex Hofer, Monika Lechleitner, Ursula Eder, Barbara Mangweth |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male Olanzapine medicine.medical_specialty medicine.drug_class medicine.medical_treatment Atypical antipsychotic Carbohydrate metabolism Benzodiazepines Islets of Langerhans Insulin resistance Internal medicine medicine Homeostasis Humans Glucose homeostasis Prospective Studies Antipsychotic Dose-Response Relationship Drug Insulin Body Weight Dopamine antagonist Pirenzepine medicine.disease Psychiatry and Mental health Endocrinology Body Composition Schizophrenia Female Insulin Resistance Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | The Journal of Clinical Psychiatry. 64:1436-1439 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.v64n1206 |
| Popis: | Background: The aim of this study was to compare glucose metabolism in patients with schizophrenia receiving olanzapine with that in control subjects. Method: We conducted a prospective, controlled, open study comparing body weight, fat mass, and indices of insulin resistance/ sensitivity in 10 olanzapine-treated patients with ICD-10 schizophrenia (olanzapine dose range, 7.5-20 mg/day) with those of a group of 10 mentally and physically healthy volunteers. Weight, fat mass, and indices of insulin resistance/sensitivity were assessed over individual 8-week observation periods from November 1997 to October 1999. Results: Fasting serum glucose and fasting serum insulin increased significantly in the olanzapine-treated patients (p = .008 for glucose and p = .006 for insulin). The homeostasis model assessment (HOMA) index for beta cell function did not change significantly in the olanzapine-treated patients, whereas the HOMA index for insulin resistance did increase (p = .006). In the control group, these parameters were stable. A significant increase in body weight (p = .001) and body fat (p = .004) was seen in patients treated with olanzapine, while the control group showed no significant changes. Conclusion: This study indicates that the disturbances in glucose homeostasis during antipsychotic treatment with olanzapine are mainly due to insulin resistance. However, beta cell function remains unaltered in olanzapine-treated patients. We conclude that treatment with some second-generation antipsychotic drugs may lead to insulin resistance. |
| Databáze: | OpenAIRE |
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