Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Autor: Mahajan, Anubha, Spracklen, Cassandra N., Zhang, Weihua, Ng, Maggie C. Y., Petty, Lauren E., Kitajima, Hidetoshi, Yu, Grace Z., Rüeger, Sina, Speidel, Leo, Kim, Young Jin, Horikoshi, Momoko, Mercader, Josep M., Taliun, Daniel, Moon, Sanghoon, Kwak, Soo-heon, Robertson, Neil R., Rayner, Nigel W., Loh, Marie, Kim, Bong-jo, Chiou, Joshua, Miguel-escalada, Irene, Della Briotta Parolo, Pietro, Lin, Kuang, Bragg, Fiona, Preuss, Michael H., Takeuchi, Fumihiko, Nano, Jana, Guo, Xiuqing, Lamri, Amel, Nakatochi, Masahiro, Scott, Robert A., Lee, Jung-jin, Huerta-chagoya, Alicia, Graff, Mariaelisa, Chai, Jin-fang, Parra, Esteban J., Yao, Jie, Bielak, Lawrence F., Tabara, Yasuharu, Hai, Yang, Steinthorsdottir, Valgerdur, Cook, James P., Kals, Mart, Grarup, Niels, Schmidt, Ellen M., Pan, Ian, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloe, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-min, Ahmad, Meraj, Noordam, Raymond, Lim, Victor J. Y., Tam, Claudia H. T., Joo, Yoonjung Yoonie, Chen, Chien-hsiun, Raffield, Laura M., Lecoeur, Cécile, Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R., Chen, Guanjie, Jensen, Richard A., Tajuddin, Salman, Kabagambe, Edmond K., An, Ping, Xiang, Anny H., Choi, Hyeok Sun, Cade, Brian E., Tan, Jingyi, Flanagan, Jack, Abaitua, Fernando, Adair, Linda S., Adeyemo, Adebowale, Aguilar-salinas, Carlos A., Akiyama, Masato, Anand, Sonia S., Bertoni, Alain, Bian, Zheng, Bork-jensen, Jette, Brandslund, Ivan, Brody, Jennifer A., Brummett, Chad M., Buchanan, Thomas A., Canouil, Mickaël, Chan, Juliana C. N., Chang, Li-ching, Chee, Miao-li, Chen, Ji, Chen, Shyh-huei, Chen, Yuan-tsong, Chen, Zhengming, Chuang, Lee-ming, Cushman, Mary, Das, Swapan K., De Silva, H. Janaka, Dedoussis, George, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Duan, Qing, Eckardt, Kai-uwe, Emery, Leslie S., Evans, Daniel S., Evans, Michele K., Fischer, Krista, Floyd, James S., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Frayling, Timothy M., Freedman, Barry I., Fuchsberger, Christian, Genter, Pauline, Gerstein, Hertzel C., Giedraitis, Vilmantas, González-villalpando, Clicerio, González-villalpando, Maria Elena, Goodarzi, Mark O., Gordon-larsen, Penny, Gorkin, David, Gross, Myron, Guo, Yu, Hackinger, Sophie, Han, Sohee, Hattersley, Andrew T., Herder, Christian, Howard, Annie-green, Hsueh, Willa, Huang, Mengna, Huang, Wei, Hung, Yi-jen, Hwang, Mi Yeong, Hwu, Chii-min, Ichihara, Sahoko, Ikram, Mohammad Arfan, Ingelsson, Martin, Islam, Md Tariqul, Isono, Masato, Jang, Hye-mi, Jasmine, Farzana, Jiang, Guozhi, Jonas, Jost B., Jørgensen, Marit E., Jørgensen, Torben, Kamatani, Yoichiro, Kandeel, Fouad R., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kaur, Varinderpal, Kawaguchi, Takahisa, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-chuen, Kibriya, Muhammad G., Kim, Duk-hwan, Kohara, Katsuhiko, Kriebel, Jennifer, Kronenberg, Florian, Kuusisto, Johanna, Läll, Kristi, Lange, Leslie A., Lee, Myung-shik, Lee, Nanette R., Leong, Aaron, Li, Liming, Li, Yun, Li-gao, Ruifang, Ligthart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Liu, Ching-ti, Liu, Jianjun, Locke, Adam E., Louie, Tin, Luan, Jian’an, Luk, Andrea O., Luo, Xi, Lv, Jun, Lyssenko, Valeriya, Mamakou, Vasiliki, Mani, K. Radha, Meitinger, Thomas, Metspalu, Andres, Morris, Andrew D., Nadkarni, Girish N., Nadler, Jerry L., Nalls, Michael A., Nayak, Uma, Nongmaithem, Suraj S., Ntalla, Ioanna, Okada, Yukinori, Orozco, Lorena, Patel, Sanjay R., Pereira, Mark A., Peters, Annette, Pirie, Fraser J., Porneala, Bianca, Prasad, Gauri, Preissl, Sebastian, Rasmussen-torvik, Laura J., Reiner, Alexander P., Roden, Michael, Rohde, Rebecca, Roll, Kathryn, Sabanayagam, Charumathi, Sander, Maike, Sandow, Kevin, Sattar, Naveed, Schönherr, Sebastian, Schurmann, Claudia, Shahriar, Mohammad, Shi, Jinxiu, Shin, Dong Mun, Shriner, Daniel, Smith, Jennifer A., So, Wing Yee, Stančáková, Alena, Stilp, Adrienne M., Strauch, Konstantin, Suzuki, Ken, Takahashi, Atsushi, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tomlinson, Brian, Torres, Jason M., Tsai, Fuu-jen, Tuomilehto, Jaakko, Tusie-luna, Teresa, Udler, Miriam S., Valladares-salgado, Adan, Van Dam, Rob M., Van Klinken, Jan B., Varma, Rohit, Vujkovic, Marijana, Wacher-rodarte, Niels, Wheeler, Eleanor, Whitsel, Eric A., Wickremasinghe, Ananda R., Van Dijk, Ko Willems, Witte, Daniel R., Yajnik, Chittaranjan S., Yamamoto, Ken, Yamauchi, Toshimasa, Yengo, Loïc, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-min, Yusuf, Salim, Zhang, Liang, Zheng, Wei, Hayes, M. Geoffrey, Raffel, Leslie J., Igase, Michiya, Ipp, Eli, Redline, Susan, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Hanis, Craig L., Peyser, Patricia A., Ingelsson, Erik, Zonderman, Alan B., Psaty, Bruce M., Wang, Ya-xing, Rotimi, Charles N., Becker, Diane M., Matsuda, Fumihiko, Liu, Yongmei, Zeggini, Eleftheria, Yokota, Mitsuhiro, Rich, Stephen S., Kooperberg, Charles, Pankow, James S., Engert, James C., Chen, Yii-der Ida, Froguel, Philippe, Wilson, James G., Sheu, Wayne H. H., Kardia, Sharon L. R., Wu, Jer-yuarn, Ma, Ronald C. W., Wong, Tien-yin, Groop, Leif, Mook-kanamori, Dennis O., Chandak, Giriraj R., Collins, Francis S., Bharadwaj, Dwaipayan, Paré, Guillaume, Sale, Michèle M., Ahsan, Habibul, Motala, Ayesha A., Shu, Xiao-ou, Park, Kyong-soo, Jukema, J. Wouter, Cruz, Miguel, Mckean-cowdin, Roberta, Grallert, Harald, Cheng, Ching-yu, Bottinger, Erwin P., Dehghan, Abbas, Tai, E-shyong, Dupuis, Josée, Kato, Norihiro, Laakso, Markku, Köttgen, Anna, Koh, Woon-puay, Palmer, Colin N. A., Liu, Simin, Abecasis, Goncalo, Kooner, Jaspal S., Loos, Ruth J. F., North, Kari E., Haiman, Christopher A., Florez, Jose C., Saleheen, Danish, Hansen, Torben, Pedersen, Oluf, Mägi, Reedik, Langenberg, Claudia, Wareham, Nicholas J., Maeda, Shiro, Kadowaki, Takashi, Lee, Juyoung, Millwood, Iona Y., Walters, Robin G., Stefansson, Kari, Myers, Simon R., Ferrer, Jorge, Gaulton, Kyle J., Meigs, James B., Mohlke, Karen L., Gloyn, Anna L., Bowden, Donald W., Below, Jennifer E., Chambers, John C., Sim, Xueling, Boehnke, Michael, Rotter, Jerome I., Mccarthy, Mark I., Morris, Andrew P.
Přispěvatelé: Epidemiology, Laboratory Genetic Metabolic Diseases, Laboratory for General Clinical Chemistry, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Genetics, 54(5), 560-572. Nature Publishing Group
Nature Genetics, 54(5), 560-+. NATURE PORTFOLIO
Nature genetics, 54(5), 560-572. Nature Publishing Group
Mahajan, A, Spracklen, C N, Zhang, W, Ng, M C Y, Petty, L E, Kitajima, H, Yu, G Z, Rüeger, S, Speidel, L, Kim, Y J, Horikoshi, M, Mercader, J M, Taliun, D, Moon, S, Kwak, S H, Robertson, N R, Rayner, N W, Loh, M, Kim, B J, Chiou, J, Miguel-Escalada, I, della Briotta Parolo, P, Lin, K, Bragg, F, Preuss, M H, Takeuchi, F, Nano, J, Guo, X, Lamri, A, Nakatochi, M, Scott, R A, Lee, J J, Huerta-Chagoya, A, Graff, M, Chai, J F, Parra, E J, Yao, J, Bielak, L F, Tabara, Y, Grarup, N, Chen, W M, Jensen, R A, Chen, J, Huang, W, Jørgensen, M E, Jørgensen, T, Witte, D R, Zhang, L, Hansen, T, Pedersen, O, FinnGen & eMERGE Consortium 2022, ' Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation ', Nature Genetics, vol. 54, no. 5, pp. 560-572 . https://doi.org/10.1038/s41588-022-01058-3
Mahajan, A, Spracklen, C N, Zhang, W, Ng, M C Y, Petty, L E, Kitajima, H, Yu, G Z, Rüeger, S, Speidel, L, Kim, Y J, Horikoshi, M, Mercader, J M, Taliun, D, Moon, S, Kwak, S-H, Robertson, N R, Rayner, N W, Loh, M, Kim, B-J, Chiou, J, Miguel-Escalada, I, Della Briotta Parolo, P, Lin, K, Bragg, F, Preuss, M H, Takeuchi, F, Nano, J, Guo, X, Lamri, A, Nakatochi, M, Scott, R A, Lee, J-J, Huerta-Chagoya, A, Graff, M, Chai, J-F, Parra, E J, Yao, J, Bielak, L F, Tabara, Y, Hai, Y, Steinthorsdottir, V, Cook, J P, Kals, M, Grarup, N, Schmidt, E M, Pan, I, Sofer, T, Wuttke, M, Sarnowski, C, Gieger, C, Nousome, D, Trompet, S, Long, J, Sun, M, Tong, L, Chen, W-M, Ahmad, M, Noordam, R, Lim, V J Y, Tam, C H T, Joo, Y Y, Chen, C-H, Raffield, L M, Lecoeur, C, Prins, B P, Nicolas, A, Yanek, L R, Chen, G, Jensen, R A, Tajuddin, S, Kabagambe, E K, An, P, Xiang, A H, Choi, H S, Cade, B E, Tan, J, Flanagan, J, Abaitua, F, Adair, L S, Adeyemo, A, Aguilar-Salinas, C A, Akiyama, M, Anand, S S, Bertoni, A, Bian, Z, Bork-Jensen, J, Brandslund, I, Brody, J A, Brummett, C M, Buchanan, T A, Canouil, M, Chan, J C N, Chang, L-C, Chee, M-L, Chen, J, Chen, S-H, Chen, Y-T, Chen, Z, Chuang, L-M, Cushman, M, Das, S K, de Silva, H J, Dedoussis, G, Dimitrov, L, Doumatey, A P, Du, S, Duan, Q, Eckardt, K-U, Emery, L S, Evans, D S, Evans, M K, Fischer, K, Floyd, J S, Ford, I, Fornage, M, Franco, O H, Frayling, T M, Freedman, B I, Fuchsberger, C, Genter, P, Gerstein, H C, Giedraitis, V, González-Villalpando, C, González-Villalpando, M E, Goodarzi, M O, Gordon-Larsen, P, Gorkin, D, Gross, M, Guo, Y, Hackinger, S, Han, S, Hattersley, A T, Herder, C, Howard, A-G, Hsueh, W, Huang, M, Huang, W, Hung, Y-J, Hwang, M Y, Hwu, C-M, Ichihara, S, Ikram, M A, Ingelsson, M, Islam, M T, Isono, M, Jang, H-M, Jasmine, F, Jiang, G, Jonas, J B, Jørgensen, M E, Jørgensen, T, Kamatani, Y, Kandeel, F R, Kasturiratne, A, Katsuya, T, Kaur, V, Kawaguchi, T, Keaton, J M, Kho, A N, Khor, C-C, Kibriya, M G, Kim, D-H, Kohara, K, Kriebel, J, Kronenberg, F, Kuusisto, J, Läll, K, Lange, L A, Lee, M-S, Lee, N R, Leong, A, Li, L, Li, Y, Li-Gao, R, Ligthart, S, Lindgren, C M, Linneberg, A, Liu, C-T, Liu, J, Locke, A E, Louie, T, Luan, J, Luk, A O, Luo, X, Lv, J, Lyssenko, V, Mamakou, V, Mani, K R, Meitinger, T, Metspalu, A, Morris, A D, Nadkarni, G N, Nadler, J L, Nalls, M A, Nayak, U, Nongmaithem, S S, Ntalla, I, Okada, Y, Orozco, L, Patel, S R, Pereira, M A, Peters, A, Pirie, F J, Porneala, B, Prasad, G, Preissl, S, Rasmussen-Torvik, L J, Reiner, A P, Roden, M, Rohde, R, Roll, K, Sabanayagam, C, Sander, M, Sandow, K, Sattar, N, Schönherr, S, Schurmann, C, Shahriar, M, Shi, J, Shin, D M, Shriner, D, Smith, J A, So, W Y, Stančáková, A, Stilp, A M, Strauch, K, Suzuki, K, Takahashi, A, Taylor, K D, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tomlinson, B, Torres, J M, Tsai, F-J, Tuomilehto, J, Tusie-Luna, T, Udler, M S, Valladares-Salgado, A, van Dam, R M, van Klinken, J B, Varma, R, Vujkovic, M, Wacher-Rodarte, N, Wheeler, E, Whitsel, E A, Wickremasinghe, A R, van Dijk, K W, Witte, D R, Yajnik, C S, Yamamoto, K, Yamauchi, T, Yengo, L, Yoon, K, Yu, C, Yuan, J-M, Yusuf, S, Zhang, L, Zheng, W, Raffel, L J, Igase, M, Ipp, E, Redline, S, Cho, Y S, Lind, L, Province, M A, Hanis, C L, Peyser, P A, Ingelsson, E, Zonderman, A B, Psaty, B M, Wang, Y-X, Rotimi, C N, Becker, D M, Matsuda, F, Liu, Y, Zeggini, E, Yokota, M, Rich, S S, Kooperberg, C, Pankow, J S, Engert, J C, Chen, Y-D I, Froguel, P, Wilson, J G, Sheu, W H H, Kardia, S L R, Wu, J-Y, Hayes, M G, Ma, R C W, Wong, T-Y, Groop, L, Mook-Kanamori, D O, Chandak, G R, Collins, F S, Bharadwaj, D, Paré, G, Sale, M M, Ahsan, H, Motala, A A, Shu, X-O, Park, K-S, Jukema, J W, Cruz, M, McKean-Cowdin, R, Grallert, H, Cheng, C-Y, Bottinger, E P, Dehghan, A, Tai, E-S, Dupuis, J, Kato, N, Laakso, M, Köttgen, A, Koh, W-P, Palmer, C N A, Liu, S, Abecasis, G, Kooner, J S, Loos, R J F, North, K E, Haiman, C A, Florez, J C, Saleheen, D, Hansen, T, Pedersen, O, Mägi, R, Langenberg, C, Wareham, N J, Maeda, S, Kadowaki, T, Lee, J, Millwood, I Y, Walters, R G, Stefansson, K, Myers, S R, Ferrer, J, Gaulton, K J, Meigs, J B, Mohlke, K L, Gloyn, A L, Bowden, D W, Below, J E, Chambers, J C, Sim, X, Boehnke, M, Rotter, J I, McCarthy, M I, Morris, A P, FinnGen & eMERGE Consortium 2022, ' Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation ', Nature Genetics, vol. 54, no. 5, pp. 560-572 . https://doi.org/10.1038/s41588-022-01058-3
2022, ' Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation ', Nature Genetics, vol. 54, no. 5, pp. 560-572 . https://doi.org/10.1038/s41588-022-01058-3
Nat. Genet. 54, 560-572 (2022)
Mahajan, A, Spracklen, C N, Zhang, W, Ng, M C Y, Petty, L E, Kitajima, H, Yu, G Z, Rüeger, S, Speidel, L, Kim, Y J, Horikoshi, M, Mercader, J M, Taliun, D, Moon, S, Kwak, S, Robertson, N R, Rayner, N W, Loh, M, Kim, B, Chiou, J, Miguel-escalada, I, Della Briotta Parolo, P, Lin, K, Bragg, F, Preuss, M H, Takeuchi, F, Nano, J, Guo, X, Lamri, A, Nakatochi, M, Scott, R A, Lee, J, Huerta-chagoya, A, Graff, M, Chai, J, Parra, E J, Yao, J, Bielak, L F, Tabara, Y, Hai, Y, Steinthorsdottir, V, Cook, J P, Kals, M, Grarup, N, Schmidt, E M, Pan, I, Sofer, T, Wuttke, M, Sarnowski, C, Gieger, C, Nousome, D, Trompet, S, Long, J, Sun, M, Tong, L, Chen, W, Ahmad, M, Noordam, R, Lim, V J Y, Tam, C H T, Joo, Y Y, Chen, C, Raffield, L M, Lecoeur, C, Prins, B P, Nicolas, A, Yanek, L R, Chen, G, Jensen, R A, Tajuddin, S, Kabagambe, E K, An, P, Xiang, A H, Choi, H S, Cade, B E, Tan, J, Flanagan, J, Abaitua, F, Adair, L S, Adeyemo, A, Aguilar-salinas, C A, Akiyama, M, Anand, S S, Bertoni, A, Bian, Z, Bork-jensen, J, Brandslund, I, Brody, J A, Brummett, C M, Buchanan, T A, Canouil, M, Chan, J C N, Chang, L, Chee, M, Chen, J, Chen, S, Chen, Y, Chen, Z, Chuang, L, Cushman, M, Das, S K, De Silva, H J, Dedoussis, G, Dimitrov, L, Doumatey, A P, Du, S, Duan, Q, Eckardt, K, Emery, L S, Evans, D S, Evans, M K, Fischer, K, Floyd, J S, Ford, I, Fornage, M, Franco, O H, Frayling, T M, Freedman, B I, Fuchsberger, C, Genter, P, Gerstein, H C, Giedraitis, V, González-villalpando, C, González-villalpando, M E, Goodarzi, M O, Gordon-larsen, P, Gorkin, D, Gross, M, Guo, Y, Hackinger, S, Han, S, Hattersley, A T, Herder, C, Howard, A, Hsueh, W, Huang, M, Huang, W, Hung, Y, Hwang, M Y, Hwu, C, Ichihara, S, Ikram, M A, Ingelsson, M, Islam, M T, Isono, M, Jang, H, Jasmine, F, Jiang, G, Jonas, J B, Jørgensen, M E, Jørgensen, T, Kamatani, Y, Kandeel, F R, Kasturiratne, A, Katsuya, T, Kaur, V, Kawaguchi, T, Keaton, J M, Kho, A N, Khor, C, Kibriya, M G, Kim, D, Kohara, K, Kriebel, J, Kronenberg, F, Kuusisto, J, Läll, K, Lange, L A, Lee, M, Lee, N R, Leong, A, Li, L, Li, Y, Li-gao, R, Ligthart, S, Lindgren, C M, Linneberg, A, Liu, C, Liu, J, Locke, A E, Louie, T, Luan, J, Luk, A O, Luo, X, Lv, J, Lyssenko, V, Mamakou, V, Mani, K R, Meitinger, T, Metspalu, A, Morris, A D, Nadkarni, G N, Nadler, J L, Nalls, M A, Nayak, U, Nongmaithem, S S, Ntalla, I, Okada, Y, Orozco, L, Patel, S R, Pereira, M A, Peters, A, Pirie, F J, Porneala, B, Prasad, G, Preissl, S, Rasmussen-torvik, L J, Reiner, A P, Roden, M, Rohde, R, Roll, K, Sabanayagam, C, Sander, M, Sandow, K, Sattar, N, Schönherr, S, Schurmann, C, Shahriar, M, Shi, J, Shin, D M, Shriner, D, Smith, J A, So, W Y, Stančáková, A, Stilp, A M, Strauch, K, Suzuki, K, Takahashi, A, Taylor, K D, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tomlinson, B, Torres, J M, Tsai, F, Tuomilehto, J, Tusie-luna, T, Udler, M S, Valladares-salgado, A, Van Dam, R M, Van Klinken, J B, Varma, R, Vujkovic, M, Wacher-rodarte, N, Wheeler, E, Whitsel, E A, Wickremasinghe, A R, Van Dijk, K W, Witte, D R, Yajnik, C S, Yamamoto, K, Yamauchi, T, Yengo, L, Yoon, K, Yu, C, Yuan, J, Yusuf, S, Zhang, L, Zheng, W, Rüeger, S, Della Briotta Parolo, P, Joo, Y Y, Hayes, M G, Raffel, L J, Igase, M, Ipp, E, Redline, S, Cho, Y S, Lind, L, Province, M A, Hanis, C L, Peyser, P A, Ingelsson, E, Zonderman, A B, Psaty, B M, Wang, Y, Rotimi, C N, Becker, D M, Matsuda, F, Liu, Y, Zeggini, E, Yokota, M, Rich, S S, Kooperberg, C, Pankow, J S, Engert, J C, Chen, Y I, Froguel, P, Wilson, J G, Sheu, W H H, Kardia, S L R, Wu, J, Hayes, M G, Ma, R C W, Wong, T, Groop, L, Mook-kanamori, D O, Chandak, G R, Collins, F S, Bharadwaj, D, Paré, G, Sale, M M, Ahsan, H, Motala, A A, Shu, X, Park, K, Jukema, J W, Cruz, M, Mckean-cowdin, R, Grallert, H, Cheng, C, Bottinger, E P, Dehghan, A, Tai, E, Dupuis, J, Kato, N, Laakso, M, Köttgen, A, Koh, W, Palmer, C N A, Liu, S, Abecasis, G, Kooner, J S, Loos, R J F, North, K E, Haiman, C A, Florez, J C, Saleheen, D, Hansen, T, Pedersen, O, Mägi, R, Langenberg, C, Wareham, N J, Maeda, S, Kadowaki, T, Lee, J, Millwood, I Y, Walters, R G, Stefansson, K, Myers, S R, Ferrer, J, Gaulton, K J, Meigs, J B, Mohlke, K L, Gloyn, A L, Bowden, D W, Below, J E, Chambers, J C, Sim, X, Boehnke, M, Rotter, J I, Mccarthy, M I & Morris, A P 2022, ' Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation ', Nature Genetics, vol. 54, no. 5, pp. 560-572 . https://doi.org/10.1038/s41588-022-01058-3
ISSN: 1061-4036
DOI: 10.1038/s41588-022-01058-3
Popis: We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background.Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
Databáze: OpenAIRE
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