Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors
| Autor: | Je Eun Kim, Young A. Kim, Hye Seung Lee, Sun Och Yoon, Gyeong Hoon Kang, Mee Soo Chang, Woo Ho Kim, Baek Hui Kim |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Gene Expression Kaplan-Meier Estimate Disease-Free Survival Pathology and Forensic Medicine Young Adult FHIT Cystadenoma Mucinous medicine Biomarkers Tumor Humans Child MUC1 beta Catenin Aged Aged 80 and over business.industry Gene Expression Profiling Mucin NF-kappa B Middle Aged medicine.disease Prognosis Adenocarcinoma Mucinous Immunohistochemistry digestive system diseases Appendix Mucinous Neoplasm medicine.anatomical_structure Appendiceal Neoplasms Tissue Array Analysis Cystadenoma Adenocarcinoma Female Tumor Suppressor Protein p53 business |
| Zdroj: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 22(8) |
| ISSN: | 1530-0285 |
| Popis: | Appendiceal mucinous neoplasms have been the focus of considerable debate in recent years. We histologically classified 70 appendiceal mucinous neoplasms into three categories: 32 mucinous adenoma, 23 mucinous neoplasm of uncertain malignant potential, and 15 mucinous adenocarcinomas. Immunohistochemistry was performed for 24 proteins in different functional categories, specifically, oncogenic proteins (bcl-2, beta-catenin, CEA, C-erbB2, c-kit, Cox-2, Cyclin D1, EGFR, Ki-67, NF-kappaB, VEGF), tumor suppressors (E-cadherin, FHIT, hMLH1, p53, p63, smad4), cell-cycle regulators (p21, p27, p16), and mucin proteins (MUC1, MUC2, MUC5AC, MUC6). Our data showed that 9 out of the 24 proteins were more frequently altered in the mucinous adenocarcinoma group than in the mucinous adenoma group (P |
| Databáze: | OpenAIRE |
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