Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death
| Autor: | T.K.Y. Lam, Kai-Hang Yiu, Raymond T.F. Cheung, Lawrence S. C. Law, A. W. K. Tso, Hung-Fat Tse, Bernard M.Y. Cheung, Lsw Li, K.S.L. Lam, A. Xu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adipokine Fatty Acid-Binding Proteins Fatty acid-binding protein Brain Ischemia Proinflammatory cytokine Brain ischemia chemistry.chemical_compound Internal medicine Adipocyte Adipocytes medicine Humans Stroke Aged business.industry Case-control study Middle Aged Prognosis medicine.disease Endocrinology chemistry Case-Control Studies Ischemic stroke Female Neurology (clinical) business Biomarkers |
| Zdroj: | Neurology. 76:1968-1975 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0b013e31821e54b3 |
| Popis: | Adipocyte fatty acid-binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality.Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index-matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke.Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3-28.4 ng/mL] vs 15.2 ng/mL [10.6-23.6 ng/mL] in men and 32.4 ng/mL [24.5-45.7 ng/mL] vs 22.0 ng/mL [14.3-34.0 ng/mL] in women, stroke vs control, p0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50-2.94, p0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18-5.96, p=0.018), independent of age and NIH Stroke Scale score.Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. |
| Databáze: | OpenAIRE |
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