Association between lactate dehydrogenase levels and oncologic outcomes in metastatic prostate cancer: A meta‐analysis

Autor: Zejia Chen, Jinlong Dai, Tianyu Zhang, Hui Xiang, Bin Xu, Shu Chen, Zisen Pang, Fan Li
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Time Factors
Disease
metastatic prostate cancer
Cochrane Library
Risk Assessment
lcsh:RC254-282
03 medical and health sciences
chemistry.chemical_compound
Prostate cancer
0302 clinical medicine
Risk Factors
Internal medicine
Lactate dehydrogenase
Biomarkers
Tumor
medicine
Humans
Radiology
Nuclear Medicine and imaging
Neoplasm Metastasis
oncologic outcome
Aged
Original Research
Aged
80 and over
L-Lactate Dehydrogenase
business.industry
Prostatic Neoplasms
lactate dehydrogenase
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Progression-Free Survival
Up-Regulation
030104 developmental biology
chemistry
Sample size determination
030220 oncology & carcinogenesis
Meta-analysis
Inclusion and exclusion criteria
Biomarker (medicine)
prognosis
business
Cancer Prevention
Zdroj: Cancer Medicine, Vol 9, Iss 19, Pp 7341-7351 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Purpose Previous studies have provided evidence of the high expression of lactate dehydrogenase (LDH) in multiple solid tumors; however, its prognostic relationship with metastatic prostate cancer (mPCa) remains controversial. We performed a meta‐analysis to better understand the prognostic potential of LDH in mPCa. Methods In our investigation, we included PubMed, Embase, Web of Science, and Cochrane Library as web‐based resources, as well as studies published before January 2020 on the predictive value of LDH in mPCa. We independently screened the studies according to the inclusion and exclusion criteria, evaluated the quality of the literature, extracted the data, and used RevMan 5.3 and STATA12.0 software for analysis. Result From the 38 published studies, the records of 9813 patients with mPCa were included in this meta‐analysis. We observed that higher levels of LDH in patients with mPCa were significantly associated with poorer overall survival (OS) (HR = 2.17, 95% CI: 1.91‐2.47, P
Our analysis suggested that lactate dehydrogenase might be a valuable biomarker, the LDH levels should be included as a valuable biomarker in the management of mPCa.
Databáze: OpenAIRE
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