Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection
| Autor: | Mattew José, C. Leroux-Robert, Jacques Dantal, Sandrine Mons, Vincent Praloran, Valérie Leprivey-Lorgeot, Jean-Claude Aldigier, Brigitte Lemauff, Yannick Le Meur |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Graft Rejection
Macrophage colony-stimulating factor medicine.medical_specialty medicine.medical_treatment Renal function Gastroenterology Internal medicine medicine Humans Rejection (Psychology) Retrospective Studies Transplantation Kidney business.industry Macrophage Colony-Stimulating Factor medicine.disease Kidney Transplantation medicine.anatomical_structure Nephrology Acute Disease Toxicity Immunology Hemodialysis business Biomarkers Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 19:1862-1865 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfh257 |
| Popis: | Background. Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and acute graft rejection. Methods. A total of 114 kidney allograft recipients were assessed for M-CSF levels by enzyme-linked immunosorbent assay (ELISA). Results. M-CSF serum levels were elevated in pre-transplant haemodialysis patients (611 ± 355 IU/ml vs 168 ± 61 in normal controls, P < 0.01). Following successful renal transplantation, M-CSF decreased in the first month, stabilizing at 257 ± 222 IU/ml (not significantly different from normal controls) in 52 post-transplant stable patients. There was no correlation between M-CSF level and creatinine clearance. M-CSF levels increased significantly (2-5 times) during biopsy-proven acute rejection episodes in 20 of 25 patients. All rejection episodes were successfully treated and serum M-CSF decreased rapidly to pre-rejection levels in 17/20 patients. In contrast, in five patients with cyclosporin toxicity and four patients with other causes of allograft dysfunction, M-CSF serum levels did not change. Conclusions. M-CSF serum level might be a specific marker of acute rejection. The source of increased production during rejection warrants further investigation, with infiltrating T cells and resident kidney cells being likely candidates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|