Valproic acid hepatic fatalities. III. U.S. experience since 1986
| Autor: | Alton E. Bryant, Fritz E. Dreifuss |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Anorexia Pharmacotherapy Risk Factors medicine Humans Child Retrospective Studies Valproic Acid Epilepsy business.industry Liver Diseases Infant Retrospective cohort study Jaundice Middle Aged United States Surgery Anticonvulsant Liver Child Preschool Vomiting lipids (amino acids peptides and proteins) Anticonvulsants Drug Therapy Combination Female Neurology (clinical) medicine.symptom Chemical and Drug Induced Liver Injury business Complication medicine.drug |
| Zdroj: | Neurology. 46(2) |
| ISSN: | 0028-3878 |
| Popis: | We report the results of a third retrospective study of the U.S. experience with fatal hepatotoxicity associated with valproic acid (VPA). In the United States, over one million patients received new prescriptions for VPA during the years 1987 to 1993, and 29 patients developed fatal hepatotoxicity. Decreased alertness, jaundice, vomiting, hemorrhage, increased seizures, anorexia, and edema were the most common presenting signs. Risk factors included young age, polytherapy, developmental delay, and coincident metabolic disorders. Patients less than 2 years old receiving VPA as polytherapy were at the greatest risk (1:600) of developing this complication. |
| Databáze: | OpenAIRE |
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