Endocrine Disorders in Autoimmune Rheumatological Diseases: A Focus on Thyroid Autoimmune Diseases and on the Effects of Chronic Glucocorticoid Treatment
| Autor: | Jacopo Giannelli, Roberta Giordano, Loredana Pagano, Mirko Parasiliti Caprino, Giulia Gaggero, Filippo Egalini, Vincenzo Cappiello, Ruth Rossetto Giaccherino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
rheumatological diseases cushing’s syndrome 030209 endocrinology & metabolism thyroid diseases Diseases of the endocrine glands. Clinical endocrinology corticosteroids 03 medical and health sciences 0302 clinical medicine Immune system medicine Genetic predisposition Endocrine system business.industry Thyroid medicine.disease RC648-665 030104 developmental biology medicine.anatomical_structure Immunology Withdrawal syndrome business Dysbiosis Glucocorticoid medicine.drug withdrawal syndrome |
| Zdroj: | Endocrines, Vol 2, Iss 18, Pp 171-184 (2021) |
| Popis: | Autoimmune rheumatological diseases’ incidence and prevalence have risen over the last decades and they are becoming increasingly important worldwide. Thyroid autoimmune diseases share with them an imbalance in the immune system that lead to a pro-inflammatory environment. Usually this is the result of a multi-factorial process. In fact, it includes not only a possible genetic predisposition, but also environmental causes like microbiota dysbiosis, diet rich in processed foods, exposure to toxicants and infections. However, many aspects are currently under study. This paper aims to examine the factors that participate in the developing of rheumatological and thyroid autoimmune diseases. Moreover, as glucocorticoids still represent a leading treatment for systemic autoimmune rheumatological diseases, our secondary aim is to summarize the main effects of glucocorticoids treatment focusing on iatrogenic Cushing’s syndrome and glucocorticoids’ withdrawal syndrome. |
| Databáze: | OpenAIRE |
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