Oxaliplatin, 5-fluorouracil/leucovorin and epirubicin as first-line treatment in advanced gastric carcinoma: a phase II study
Autor: | Desire' Pantalone, Virginia Rotella, P. Tonelli, A. Mercatelli, Pietro Pantaleo, Antonio Taddei, Costanza Paoletti, Bruno Neri, Elisa Giommoni, Raffaella Grifoni |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Organoplatinum Compounds medicine.medical_treatment Leucovorin Phases of clinical research Bone Neoplasms Adenocarcinoma chemotherapy Gastroenterology Internal medicine Antineoplastic Combined Chemotherapy Protocols Clinical Studies medicine 5-fluorouracil Chemotherapy Epirubicin Gastric cancer Oxaliplatin Aged Colorectal Neoplasms Female Fluorouracil Humans Liver Neoplasms Middle Aged Prognosis Survival Rate Oncology Stomach cancer Survival rate business.industry gastric cancer oxaliplatin medicine.disease Surgery Regimen business medicine.drug |
Zdroj: | British Journal of Cancer |
ISSN: | 1532-1827 0007-0920 |
Popis: | The association between oxaliplatin and 5-fluorouracil (5-FU) has been extensively reported to improve prognosis of gastric cancer patients. The present study is aimed at evaluating response rate and the toxicity profile of the association with oxaliplatin, 5-FU/lecovorin and epirubicin in gastric cancer patients with locally advanced or metastatic disease. Thirty-six patients have been enrolled and 35 evaluated. The treatment schedule was oxaliplatin (100 mg m(-2)), 5-FU (400 mg m(-2)), leucovorin (40 mg m(-2)) and epirubicin (60 mg m(-2)) intravenously. administered every 3 weeks for 6 months, for a total of 185 therapy cycles . Response rate and toxicity were assessed according to the international WHO criteria. Every patient received a mean of 5.3 therapy cycles in a day-hospital setting. Sixteen of 35 patients (46%) showed an objective response, two complete response and 14 partial response. Median time to progression was 33 weeks with an overall median survival of 49 weeks. During the study, anaemia grade 3 and neutropenia grade 3 were observed in 9 and 11% of patients respectively. A grade 3 periferic sensorial neuropathy was observed in 6% of patients. No life threatening or cardiac toxicity was recorded. The regimen used showed anticancer activity against gastric carcinoma, a tolerable toxicity profile and excellent patient compliance. |
Databáze: | OpenAIRE |
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