Defining the Turkey MHC: Sequence and Genes of the B Locus
| Autor: | L. D. Chaves, Stacy B. Krueth, Kent M. Reed |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Genetics
Turkeys Polymorphism Genetic biology Immunology Haplotype chemical and pharmacologic phenomena Locus (genetics) Major histocompatibility complex biology.organism_classification Major Histocompatibility Complex Haplotypes Gene mapping Genetic linkage biology.protein Animals Immunology and Allergy Chickens Meleagris gallopavo Gene Synteny |
| Zdroj: | The Journal of Immunology. 183:6530-6537 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.0901310 |
| Popis: | The MHC, the most polymorphic and gene dense region in the vertebrate genome, contains many loci essential to immunity. In mammals, this region spans ∼4 Mb. Studies of avian species have found the MHC to be greatly reduced in size and gene content with an overall locus organization differing from that of mammals. The chicken MHC has been mapped to two distinct regions (MHC-B and -Y) of a single chromosome. MHC-B haplotypes possess tightly linked genes encoding the classical MHC molecules and few other disease resistance genes. Furthermore, chicken haplotypes possess a dominantly expressed class I and class II B locus that have a significant effect on the progression or regression of pathogenic disease. In this study, we present the MHC-B region of the turkey (Meleagris gallopavo) as a similarly constricted locus, with 34 genes identified within a 0.2-Mb region in near-perfect synteny with that of the chicken MHC-B. Notable differences between the two species are three BG and class II B loci in the turkey compared with one BG and two class II B loci in the chicken MHC-B. The relative size and high level of similarity of the turkey MHC in relation to that of the chicken suggest that similar associations with disease susceptibility and resistance may also be found in turkey. |
| Databáze: | OpenAIRE |
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