Antral gastrin concentration in gastric ulcer disease. The finding of high concentrations in a few patients
| Autor: | Gary Van Deventer, Steven N. Becker, William S. Hughes, Marc Shabot |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology medicine.medical_treatment Pyloroplasty Gastroenterology Internal medicine Gastrins medicine Humans Stomach Ulcer Antrum Gastrin Aged medicine.diagnostic_test business.industry Stomach digestive oral and skin physiology Hepatology Middle Aged Vagotomy Curvatures of the stomach digestive system diseases Endoscopy stomatognathic diseases medicine.anatomical_structure Gastric Mucosa Female business |
| Zdroj: | Digestive diseases and sciences. 25(8) |
| ISSN: | 0163-2116 |
| Popis: | Antral gastrin concentratin (AGC) was measured in forceps biopsy specimens of prepyloric mucosa obtained at endoscopy in 65 patients with various kinds of gastric ulcer and in 31 nonulcer control patients. AGC in 32 patients with a lesser curvature gastric ulcer, 10.0 +/- 2.0 (mean +/- 1 SE) ng gastrin/mg tissue was significantly less (P0.01) than AGC in 31 nonulcer control patients, 14.4 +/- 1.4. AGC was similar to the control values in 23 patients with a pyloric channel ulcer, 15.2 +/- 1.7; 5 patients with a greater curvature ulcer, 15.0 +/- 4.8; and 3 patients with both duodenal and gastric ulcers, 15.8 +/- 0.7. AGC was significantly greater (P0.01) than the control values in 3 patients with a vagotomy and pyloroplasty and a gastric ulcer, 29.8 +/- 5.0. In contrast with most lesser curvature gastric ulcer patients who had low AGC, 3 gastric ulcer patients had antral gastrin values which were about three times the mean AGC of the controls. Two of these patients had fasting serum gastrin values which were more than twice the mean control fasting serum gastrin. Meal-stimulated integraed gastrin responses in these 3 patients ranged from three to nine times the mean control response. These findings suggest that a high AGC may account for a few instances of increased serum gastrin concentrations in gastric ulcer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink