Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
| Autor: | Wei Wu, Andrei Glinka, Hajo Delius, Claudia Blumenstock, Christof Niehrs, A. Paula Monaghan |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cell signaling
animal structures Protein family Xenopus Molecular Sequence Data Embryonic Development Xenopus Proteins Proto-Oncogene Proteins Gene expression Animals Cloning Molecular Genetics Embryonic Induction Multidisciplinary biology Wnt signaling pathway Proteins Zebrafish Proteins biology.organism_classification Cell biology Wnt Proteins Secretory protein DKK1 Multigene Family embryonic structures Intercellular Signaling Peptides and Proteins Signal transduction Head Signal Transduction |
| Zdroj: | Nature. 391(6665) |
| ISSN: | 0028-0836 |
| Popis: | The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|