Effect of high-fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects

Autor:	Kang Yu, Liming Zhu, Ning Wang, Wen Juan Fan, Yuan Tao Hou, Zhi Feng Wang, Xiao Qing Li, Xiaohong Sun, Jing Nan Li, Xiu Cai Fang, Meng Guo, Mei Yun Ke
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Esophageal pH Monitoring Adolescent Nerd Manometry Diet High-Fat Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Interquartile range Functional Food Internal medicine medicine Humans Reflux esophagitis Aged Meal business.industry Stomach digestive oral and skin physiology Gastric Acidity Determination Hydrogen-Ion Concentration Middle Aged medicine.disease digestive system diseases medicine.anatomical_structure Postprandial 030220 oncology & carcinogenesis Case-Control Studies GERD Gastroesophageal Reflux Gastric acid 030211 gastroenterology & hepatology Female Esophagogastric Junction business
Zdroj:	Journal of digestive diseases. 19(11)
ISSN:	1751-2980
Popis:	OBJECTIVES To investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH. METHODS We enrolled patients with reflux esophagitis (RE; n = 15), nonerosive reflux disease (NERD; n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and isovolumetric high-fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared. RESULTS High-fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high-fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378379fd1220db9bc3ba12b31e216e98 https://pubmed.ncbi.nlm.nih.gov/30270576 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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