Response to suxamethonium in a myasthenic patient during remission

Autor:	M. Abel, N. Patel, J. B. Eisenkraft
Rok vydání:	1991
Předmět:	Male Biopsy Neuromuscular Junction Neuromuscular transmission Succinylcholine Vocal Cords Electromyography Asymptomatic Myasthenia Gravis medicine Humans Anesthesia Depression (differential diagnoses) ED50 Dose-Response Relationship Drug medicine.diagnostic_test Cumulative dose business.industry Remission Induction Middle Aged medicine.disease Myasthenia gravis Anesthesiology and Pain Medicine medicine.symptom business Muscle Contraction
Zdroj:	Anaesthesia. 46:30-32
ISSN:	1365-2044 0003-2409
DOI:	10.1111/j.1365-2044.1991.tb09310.x
Popis:	A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed myasthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08 mg/kg and 0.20 mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90-95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.
Databáze:	OpenAIRE
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