The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation
| Autor: | Ji-Long Zhou, Jin-Peng Zhang, Mei-Rong Zhang, Qiang Ju, Zhen Ding, Li-Chun Xu, Xiao-Long Zhou, Qiao-Mei Shi, Hui Wang, Xing Ge, Qi Wang, Hong-Min Yu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Clinical Biochemistry Immunology 03 medical and health sciences 0302 clinical medicine Nuclear Receptor Coactivator 1 Cell Line Tumor LNCaP Immunology and Allergy Humans Nuclear Receptor Co-Repressor 2 Receptor Thyroid hormone receptor Retinoid X receptor alpha Chemistry Interleukin-6 Prostatic Neoplasms Retinoid X receptor gamma Neoplasm Proteins Androgen receptor 030104 developmental biology Hormone receptor Receptors Androgen 030220 oncology & carcinogenesis Cancer research Retinoid X receptor beta |
| Zdroj: | European cytokine network. 27(4) |
| ISSN: | 1952-4005 |
| Popis: | The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the absence of androgens to induce prostate cancer progression. The purpose of this study was to investigate whether the co-activator steroid receptor coactivator-1 (SRC-1) and co-repressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) are involved in IL-6-induced AR activation. The effects of IL-6 on LNCaP cell proliferation were monitored using real-time cell analysis (RTCA) iCELLigence system. The impacts of IL-6 on the association of the AR with SRC-1 and SMRT were investigated using the mammalian two-hybrid assay. IL-6 increased the proliferation of LNCaP cells with maximal induction at 50 ng/mL. The AR-SRC-1interaction was enhanced by IL-6, with maximal induction at the concentration of 50 ng/mL (P |
| Databáze: | OpenAIRE |
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