Immunomodulatory effects of Echinacea and Pelargonium on the innate and adoptive immunity in calves

Autor:	Juergen A. Richt, Aysun Yilmaz, Utku Y. Cizmecigil, Cuneyt Seckin, Gamze Alpun Kalayci, Huseyin Yilmaz, Nuri Turan, Ozge Aydin
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine 040301 veterinary sciences igg Agriculture (General) Immunology Pelargonium sidoides γ interferon S1-972 0403 veterinary science 03 medical and health sciences Echinacea (animal) pelargonium pcr Immunity cytokine γ-interferon calf biology Traditional medicine 04 agricultural and veterinary sciences Pelargonium RC581-607 biology.organism_classification immunity 030104 developmental biology Adoptive immunity Immunologic diseases. Allergy echinacea Agronomy and Crop Science Food Science
Zdroj:	Food and Agricultural Immunology, Vol 29, Iss 1, Pp 744-761 (2018)
ISSN:	1465-3443 0954-0105
Popis:	Immunomodulatory effects of Echinacea purpurae and Pelargonium sidoides in calves were investigated. Sixty 25-day-old nonvaccinated calves living in integrated farm unit were randomly selected and were divided into 5 treatment groups consisting of 12 calves each; 4 groups were receiving different amounts and/or times of Echinacea and Pelargonium and the control group received placebo. Blood levels of γ-interferon, cytokine gene expression, lactoferrin and total IgG were analysed on days 0, 9, and 30. When levels for total IgG, γ-interferon, mRNAs for the γ-interferon, IL-1-β, IL-4 and the tumour necrosis factor-α genes were compared from days 0 to 9 post-treatment, significant differences were found between treated and non-treated calves using various amounts of Echinacea and Pelargonium; a doses of 250 mg Echinacea and 62.5 mg Pelargonium for 5 days seems to be ideal. Echinacea purpurae and Pelargonium sidoides are able to modulate immune functions in calves.
Databáze:	OpenAIRE
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