Continuing efforts on the improvement of Beckmann rearrangement of indanone oxime
| Autor: | Takao Nishi, Jun-ichi Minamikawa, Yasuhiro Torisawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Methanesulfonyl chloride
Clinical Biochemistry Pharmaceutical Science chemistry.chemical_element Ionic bonding Biochemistry Medicinal chemistry Catalysis Indanone oxime chemistry.chemical_compound Oximes Drug Discovery Beckmann rearrangement Organic chemistry Lewis acids and bases Molecular Biology Mesylates Phosphorus fungi Organic Chemistry General Medicine Oxime Amides Lewis acid catalysis chemistry Reagent Indans Solvents Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:448-452 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2006.10.019 |
| Popis: | Continuing search for beneficial additive toward the Beckmann rearrangement (BR) of indanone oxime has revealed that common Lewis acid catalyst in methanesulfonyl chloride (MsCl) showed increasing efficiency in this ionic rearrangement. The new protocol with MsCl is superior to the classical phosphorus-based methods such as PPA and Eaton reagent, especially in the reaction of indanone oximes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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