Euler-Lagrange analysis towards representative down-scaling of a 22m3 aerobic S. cerevisiae fermentation
| Autor: | Henk J. Noorman, Amit T. Deshmukh, Robert F. Mudde, Cees Haringa |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine Engineering Scale (ratio) Chemistry(all) General Chemical Engineering Down scaling Industrial scale 01 natural sciences Industrial and Manufacturing Engineering 03 medical and health sciences Euler lagrange 010608 biotechnology Bioreactor Scale-down Mixing (physics) Simulation Ideal (set theory) business.industry Applied Mathematics Euler-Lagrange General Chemistry Mechanics 030104 developmental biology Scientific method Fermentation Chemical Engineering(all) CFD business |
| Zdroj: | Chemical Engineering Science, 170 |
| ISSN: | 0009-2509 |
| DOI: | 10.1016/j.ces.2017.01.014 |
| Popis: | With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the process performance. The influence of extra-cellular variations on the organism can be tested using so-called scale-down simulators, laboratory scale setups where deliberate, controlled fluctuations are imposed in the extra-cellular environment. |
| Databáze: | OpenAIRE |
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