Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
| Autor: | Sonja I. Berndt, Yong Zhu, Tongzhang Zheng, Stephen J. Chanock, Peter Boyle, Bing Zhang, Brian P. Leaderer, Meredith Yeager, Kaiyong Zou, Robert Welch, Shelia Hoar Zahm, Theodore R. Holford, Nathaniel Rothman, Sophia S. Wang, Qing Lan, Min Shen, Yawei Zhang |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Immunology Population Single-nucleotide polymorphism Biology Biochemistry Th2 Cells immune system diseases Genotype medicine Humans Genetic Predisposition to Disease Allele education Aged Retrospective Studies education.field_of_study Polymorphism Genetic Neoplasia Lymphoma Non-Hodgkin Racial Groups Haplotype Case-control study Chromosome Mapping DNA Neoplasm Cell Biology Hematology Odds ratio Middle Aged Th1 Cells medicine.disease Lymphoma Case-Control Studies Cytokines |
| Zdroj: | Blood. 107:4101-4108 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 candidate Th1/Th2 genes in a population-based case-control study of non-Hodgkin lymphoma (NHL; n = 518 cases, 597 controls) among women in Connecticut. SNPs in critical genes, IL4, IL5, IL6, and IL10, were associated with risk for NHL and in some instances with a specific histologic subtype. Analysis of 4 SNPs in the IL10 promoter (–3575T>A, –1082A>G, –819C>T, and –592C>A) revealed that both the AGCC haplotype (odds ratio [OR] = 1.54, 95% confidence interval [CI] = 1.21-1.96, P < .001) and the TATA haplotype (OR = 1.37, 95% CI = 1.05-1.79, P = .02) were associated with increased risk for B-cell lymphomas. In contrast, the IL4-1098G allele was associated with increased risk of T-cell lymphomas (OR = 3.84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL. |
| Databáze: | OpenAIRE |
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