Comparison Of Cimicifuga foetida extract and different hormone therapies regarding in causing breast pain in early postmenopausal women
| Autor: | Di Ma, Ya-Ping Wang, Yan Deng, Xiao-Tong Cheng, Ai-Jun Sun, Si-Jia Zhang, Wei Xue, Yan-Fang Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Cimicifuga Endocrinology Diabetes and Metabolism Breast pain 030209 endocrinology & metabolism Medroxyprogesterone Acetate 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Cimicifuga foetida Humans Progesterone Postmenopausal women Estradiol business.industry Plant Extracts Obstetrics and Gynecology Estrogens Middle Aged Postmenopause Treatment Outcome 030220 oncology & carcinogenesis Drug Therapy Combination Female Menopausal hormone therapy medicine.symptom Progestins business Mastodynia Hormone Phytotherapy |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 35(2) |
| ISSN: | 1473-0766 |
| Popis: | This study aimed to compare the influence between Cimicifuga foetida extract and different hormone therapies on breast pain in early postmenopausal women. A prospective, randomized, controlled clinical trial was conducted among 96 early postmenopausal women. Participants were randomly assigned to three groups: group A received 1 mg/day estradiol valerate plus 4 mg/day medroxyprogesterone acetate on days 19-30; group B received 1 mg/day estradiol valerate plus 100 mg/day micronized progesterone on days 19-30; group C received C. foetida extract, 1talet (contains 33.3 mg extract), t.i.d. Breast pain diary and numerical rating scale was used to access the breast pain. For 6 months' treatment, the total incidence of breast pain in group A and B was significantly higher than that in group C (p .05). The duration (day) of breast pain in each month decreased over time in group A and B while it was continuously low and without significant change in group C (p .05). The intensity of breast pain was mild in most participants and did not differ among three groups (p .05). During treatment of early postmenopausal women with C. foetida extract for 6 months, the incidence and duration of breast pain were lower than upon treatment with E2 plus cyclic MPA or m-P and did not change over time. |
| Databáze: | OpenAIRE |
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