Genetic Evaluation of Suspected Cases of Transient HIV-1 Infection of Infants
| Autor: | James I. Mullins, Jia Qi Zhao, Lisa M. Frenkel, Raymond J. Apple, Steven M. Wolinsky, Ashley T. Haase, Gerald H. Learn, Irvin S. Y. Chen, Abdallah Harmache, Laura Manns-Arcuino, Xi C. He, Anup Madan, Donald M. Thea, Norbert J. Roberts, Richard A. Koup, Paul Krogstad, Bette T. Korber, Leroy Hood, Katherine Staskus, Belinda L. Herring, Richard W. Steketee, Mary Zupancic, Robert W. Coombs, David D. Ho, Joan E. Nichols, Marcia L. Kalish, Shan-Lu Liu, David Muthui, Savita Pahwa |
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| Rok vydání: | 1998 |
| Předmět: |
Pediatrics
medicine.medical_specialty Molecular Sequence Data HIV Infections Viremia Biology Genes env Polymerase Chain Reaction Virus Specimen Handling Acquired immunodeficiency syndrome (AIDS) Immunopathology Genotype medicine Humans Diagnostic Errors Sida Phylogeny Multidisciplinary Infant Newborn Infant biology.organism_classification medicine.disease Infectious Disease Transmission Vertical DNA Viral Immunology Lentivirus HIV-1 Equipment Contamination RNA Viral Female Viral disease T-Lymphocytes Cytotoxic |
| Zdroj: | Science. 280:1073-1077 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Detection of human immunodeficiency virus–type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1envsequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented. |
| Databáze: | OpenAIRE |
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