Patient Preferences for Endometriosis Pain Treatments in the United States
| Autor: | Cheryl L. Renz, Sanjay K. Agarwal, Joshua Posner, Ahmed M. Soliman, Christine Poulos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Moderate to severe medicine.medical_specialty Endometriosis Patient characteristics Discrete choice experiment Logistic regression 03 medical and health sciences 0302 clinical medicine Dysmenorrhea Surveys and Questionnaires Humans Pain Management Medicine 030212 general & internal medicine Pain Measurement business.industry 030503 health policy & services Health Policy Pelvic pain Public Health Environmental and Occupational Health Patient Preference Bone fracture Middle Aged medicine.disease Patient preference United States Physical therapy Female Self Report medicine.symptom 0305 other medical science business |
| Zdroj: | Value in Health. 22:728-738 |
| ISSN: | 1098-3015 |
| DOI: | 10.1016/j.jval.2018.12.010 |
| Popis: | Objectives To quantify patient preferences for endometriosis-associated pain treatments and risk tolerance in exchange for pain reduction and to explore whether preferences vary on the basis of patient characteristics. Methods US women with a self-reported physician diagnosis of endometriosis and moderate to severe dysmenorrhea and nonmenstrual pelvic pain (NMPP) completed an online discrete choice experiment survey. Each choice question had a pair of hypothetical treatments characterized by attributes with varying levels: improvements in severe dysmenorrhea, severe NMPP, and severe dyspareunia; mode of administration; and treatment-related risks of pregnancy-related problems, bone fracture later in life, and moderate to severe hot flashes. A random-parameters logit model was used to quantify preferences and the attributes' conditional relative importance. Results A total of 250 women (mean age 34 years) completed the survey. The conditional relative importance of attributes was 3.66 for risk of moderate to severe hot flashes among respondents with and 3.58 among respondents without experience with moderate to severe hot flashes; 1.70, 1.49, and 1.48 for improvements in dyspareunia, NMPP, and dysmenorrhea, respectively; 0.60 for risk of pregnancy-related problems; 0.53 for mode of administration; and 0.49 for bone fracture risk. Preference weights for bone fracture risk levels were not statistically significantly different. In exchange for a greater improvement in dysmenorrhea from severe to mild (vs moderate), respondents without a history of hot flashes accepted a greater increase in the risk of moderate to severe hot flashes (38%) than did respondents with this history (16%). Conclusions Respondents placed the greatest weight on risk of hot flashes, followed by improvements in dyspareunia, NMPP, dysmenorrhea. Bone fracture risk did not drive preferences. |
| Databáze: | OpenAIRE |
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