Pyrazinamide enhances persistence of T-cell memory induced by tuberculosis subunit vaccine LT70

Autor:	Hongxia, Niu, Chunxiang, Bai, Fei, Li, Lan, Ma, Juanjuan, He, Xintong, Shi, Xue, Han, Bingdong, Zhu, Ying, Zhang
Rok vydání:	2022
Předmět:	CD4-Positive T-Lymphocytes Microbiology (medical) Antigens Bacterial Immunology Mycobacterium tuberculosis Pyrazinamide Microbiology Mice Inbred C57BL Mice Infectious Diseases Vaccines Subunit Animals Tuberculosis Tuberculosis Vaccines Immunologic Memory
Zdroj:	Tuberculosis. 135:102220
ISSN:	1472-9792
DOI:	10.1016/j.tube.2022.102220
Popis:	Repurposing anti-tuberculosis drugs with adjuvant properties in vaccination has double benefits for the control of tuberculosis. In this study, to verify the immunomodulatory effect of the tuberculosis drug pyrazinamide (PZA) on tuberculosis subunit vaccine-induced memory T cell response, we treated mice with PZA during the course of vaccination and then monitored the vaccine-specific T cell memory responses. Compared with the mice that received LT70 alone, we found that the mice co-administrated with PZA and LT70 did not produce a higher frequency of multifunctional CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377852503e31637afccda67e6baa657d https://doi.org/10.1016/j.tube.2022.102220 Zobrazit plný text záznamu Full Text from ScienceDirect