| Popis: |
Background: Pre-eclampsia is a serious pregnancy-related disease that affects both mother and fetus affects 3-7 percent of pregnancies globally.Exact etiology of this complicated disease remains unknown with other numerous mechanisms low levels of vitamin D is also hypothesized to contribute inits etiology.Vitamin D deficiency is reported as epidemic across the globe, as high as 62%, with a female predisposition of around 50%, also common in pregnant women in several parts of the world.This study is intended to conclude the vitamin D status and VDR gene, with its relation in spiral artery remodeling in normal and pre eclamptic women. Methods:This cross-sectional study was conducted in Department of Anatomy with collaboration of Department of Gynecology and Obstetrics of Liaquat University Hospital Hyderabad and Jamshoro after ethical approval on placentae of 122 parturients;61 from normal and 61 from preeclampsia, data was collected on predesigned proforma, and was analyzed on SPSS 21. Results:Mean��SD of maternal age, parity and gestational age (in weeks), wall thickness of spiral artery and % of VDR positive cells of study participants were 32.7 years��5.9, 3.9��1.4, 37.3��3.6, 48.11��23.5295 and , 46.49��18.779 respectively. (table1). Mean and SD of vitamin D levels and placental weight (table2) and wall thickness of spiral artery and % of VDR positive stained cells when compared on image J software between healthy and preeclamptic patients is highly significant.(table 3) Conclusions: Abnormal remodeling of spiral artery is significantly associated with low levels of Vitamin D and its receptors, leading to placental diseases such as preeclampsia. |
