Role of Hematopoietic Cells in the Maintenance of Chronic Human Torquetenovirus Plasma Viremia
| Autor: | Fabrizio Maggi, Mario Petrini, Maria Linda Vatteroni, Mauro Bendinelli, Daniele Focosi, Mauro Pistello, Luca Ceccherini-Nelli, Letizia Lanini, M Albani |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_treatment Immunology Viremia Hematopoietic stem cell transplantation Biology Microbiology Plasma Virology medicine Humans DNA Viruses Hematopoietic Stem Cell Transplantation Middle Aged Viral Load medicine.disease Hematopoietic Stem Cells Haematopoiesis Leukemia Viral replication Insect Science DNA Viral Pathogenesis and Immunity Female Viral disease Stem cell Viral load |
| Popis: | Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia. |
| Databáze: | OpenAIRE |
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