SLAM family receptors control pro-survival effectors in germinal center B cells to promote humoral immunity

Autor:	Jin Qian, Lingli Dong, Astrid Zahn, André Veillette, Irah L. King, Danielle Karo-Atar, Yan Lu, Javier M. Di Noia, Yingzi Zhu, Ming-Chao Zhong
Rok vydání:	2020
Předmět:	Cell Survival T-Lymphocytes Immunology Plasma Cells Dose-Response Relationship Immunologic Apoptosis Cell Count Signaling Lymphocytic Activation Molecule Family Insights Antibodies 03 medical and health sciences 0302 clinical medicine Signaling lymphocytic activation molecule Antigen Bone Marrow Immunology and Allergy Animals 030304 developmental biology Cell Proliferation Mice Knockout 0303 health sciences B-Lymphocytes Nematospiroides dubius biology Effector Chemistry Cell Cycle Vaccination breakpoint cluster region Germinal center T-Lymphocytes Helper-Inducer Germinal Center Immunoglobulin Class Switching Cell biology Immunity Humoral Proto-Oncogene Proteins c-bcl-2 Antigens Helminth Humoral immunity Antibody Formation biology.protein Immunization Somatic Hypermutation Immunoglobulin Antibody Immunologic Memory 030215 immunology Signal Transduction
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538
Popis:	SLAM family receptors are involved in humoral immune regulation. In this issue of JEM, Zhong et al. provide evidence that these receptors collectively suppress germinal center reaction but promote production of antigen-specific antibodies. SLAM family receptors are involved in humoral immune regulation. In this issue of JEM, Zhong et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20200756) provide evidence that these receptors collectively suppress germinal center reaction but promote production of antigen-specific antibodies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3770062376150f5aef193e28f789024b https://pubmed.ncbi.nlm.nih.gov/33570568 Zobrazit plný text záznamu