Drug eluting stents versus bare metal stents in the treatment of saphenous vein graft disease: a systematic review and meta-analysis
| Autor: | William J. van Gaal, Roberto Latini, Emmanouil S. Brilakis, Ravinay Bhindi, Stefania Lanotte, Adrian P. Banning, Pierfrancesco Agostoni, Nedy Brambilla, Paul Vermeersch, Luca Testa, Francesco Bedogni, Giuseppe Biondi-Zoccai, Samuele Pizzocri, Maria Luisa Laudisa |
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| Rok vydání: | 2010 |
| Předmět: |
Bare-metal stent
Target lesion medicine.medical_specialty medicine.medical_treatment Internal medicine Angioplasty medicine Humans Saphenous Vein Myocardial infarction Angioplasty Balloon Coronary Coronary Artery Bypass Adverse effect business.industry Graft Occlusion Vascular Drug-Eluting Stents medicine.disease Surgery Drug-eluting stent Meta-analysis Number needed to treat Cardiology Stents Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1774-024X |
| DOI: | 10.4244/eij30v6i4a87 |
| Popis: | AIMS: Treatment of saphenous vein graft (SVG) disease is still a matter of debate given the uncertainty of the available conflicting data. Our aim was to assess, by means of a meta-analytic approach, the risk/benefit profile of drug eluting stents (DES) versus bare metal stents (BMS) in the treatment of SVG disease. METHODS AND RESULTS: A search of relevant studies in several databases was performed. The endpoints of interest such as: major adverse events (MAE) (the combination of overall death and non-fatal myocardial infarction [AMI]), target vessel revascularisation (TVR), and target lesion revascularisation (TLR) have been calculated in-hospital and at the longest follow-up. Single endpoints and the rate of stent thrombosis (ST) were also assessed. Three randomised controlled trials and 15 registry studies were appraised, totalling 3,294 patients. During hospitalisation, there was no difference in the risk of MAE, overall death, AMI and TVR. No data were available to calculate the TLR rate. At a mean follow-up of 19.8 months, no significant differences were found in the risk of MAE and AMI. BMS were associated with a trend towards a higher risk of overall death (OR 1.32 [1,00-1.74], p=0.05, number needed to treat [NNT]=55). DES showed superiority in terms of TVR (OR 1.86 [1.33-2.61], p=0.0003, NNT=16), and TLR (OR 1.77 [1.27-2.48], p |
| Databáze: | OpenAIRE |
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