| Popis: |
Vascular thrombosis is a life-threatening condition caused by the formation of blood clots in the blood vessels. Thrombolytic therapy is a commonly used treatment for this condition. However, conventional thrombolytic agentshave limitations, including a short therapeutic window and an increased risk of bleeding. Natural products havegained attention as alternative sources of thrombolytic agents due to their lower side effect profiles. Homoeopathicmedicine Cactus grandiflorus, traditionally used for the treatment of cardiovascular diseases, has several bioactivecompounds that possess various pharmacological activities. In this study, we conducted in silico docking studies to evaluate the thrombolytic properties of Cactus grandiflorus byactivation of tissue-plasminogen activator (tPA). The in silico studies involved computer simulations to predict thebinding affinity of the bioactive compounds like Narcissin, Rutin and Kaempferitrin in Cactus grandiflorus with tPA. The results showed that the bioactive compounds Rutin and Kaempferitrin in Cactus grandiflorus had high bindingaffinity with tPA, indicating that the plant has the potential to act as a thrombolytic agent. The findings of this study provide a theoretical basis for the use of Cactus grandiflorus as a potential therapeuticagent for vascular thrombosis. Further studies, including in vitro and in vivo experiments, are required to confirm thethrombolytic properties of Cactus grandiflorus and to determine its safety and efficacy as a therapeutic agent. If proven effective, Cactus grandiflorus could provide a safe and effective alternative to conventional thrombolyticagents for the treatment of vascular thrombosis. |
