Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
| Autor: | Rodrigo Moreno S, Waldo Sepúlveda L., Guillermo Pérez G, Edgardo Corral S., María Elena Ojeda B, Mauricio Reascos M, Hernán Valenzuela G |
|---|---|
| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2006 |
| Předmět: |
Pediatrics
medicine.medical_specialty Acrania Folic acid business.industry Incidence (epidemiology) Flour Neural tube food and beverages Nervous system malformations General Medicine medicine.disease Dietary supplements Surgery Folic acid fortification medicine.anatomical_structure medicine business |
| Zdroj: | Revista médica de Chile v.134 n.9 2006 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Background: In Chile, flour is fortified with folic acid since 2000, and the incidence of neural tube defects has decreased. Cranio-encephalic congenital defects (CECD) have a wider clinical scope, includind classical neural tube defects (NTD) such as anencephalia and acrania, but also incorporating other defects. Therefore, the effects of folic acid fortification on the incidence of CECD could be different. Aim: To study the effect of folic acid fortification on the incidence of CECD. Material and methods: All prenatal diagnoses of CECD and cases registered locally in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were reviewed. The obtained data were crossed with all death certificates of newborns or stillborns of more than 500 g in the Sixth Region, in Central Chile. All cases were classified again in four subtypes, according to their phenotype. The incidences of all subtypes prior (1996-2000) and after folic acid supplementation (2001-2004), were compared. Results: Between 1996 and 2004, there were 64 cases of CEDC among 109,176 infants born alive. The global rate was 8.86 per 10,000 born alive in the period prior to fortification and 3.03 per 10,000 born alive after fortification. Comparing both periods, there was a 66% reduction in all CECD and a 77 and 100% reduction in subtypes A and B of CECD, respectively (p |
| Databáze: | OpenAIRE |
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