Traffic-related air pollution and prostate cancer risk: a case–control study in Montreal, Canada
| Autor: | Dan L. Crouse, Alexandre Liautaud, Nancy A. Ross, Marie-France Valois, Hong Chen, Mark S. Goldberg, Marie-Élise Parent |
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| Přispěvatelé: | Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Department of Medecine [Montréal], McGill University = Université McGill [Montréal, Canada], Division of Clinical Epidemiology, McGill University = Université McGill [Montréal, Canada]-Royal Victoria Hospital, McGill University Health Center [Montreal] (MUHC)-McGill University Health Center [Montreal] (MUHC), Environmental Health Sciences and Research Bureau (HECSB), Health Canada, Department of Geography [Montréal], Public Health Ontario - Santé publique Ontario, School of Population and Public Health, University of British Columbia (UBC), This study was supported financially through grants from the Canadian Cancer Society, the Cancer Research Society, the Fonds de la recherche du Québec—Santé (FRQS), FRQS-RRSE, the Ministère du Développement économique, de l'Innovation et de l'Exportation du Québec, and the Canadian Institutes for Health Research. |
| Rok vydání: | 2013 |
| Předmět: |
Male
MESH: Quebec Index date [SDV]Life Sciences [q-bio] Air pollution MESH: Logistic Models 010501 environmental sciences Logistic regression medicine.disease_cause 01 natural sciences Prostate cancer 0302 clinical medicine Risk Factors MESH: Risk Factors Medicine 030212 general & internal medicine Vehicle Emissions MESH: Aged Prostate cancer risk MESH: Middle Aged Confounding Quebec Middle Aged MESH: Case-Control Studies 3. Good health MESH: Vehicle Emissions Adult MESH: Air Pollution Nitrogen Dioxide MESH: Environmental Exposure MESH: Nitrogen Dioxide 03 medical and health sciences Environmental risk Air Pollution Environmental health Humans Aged 0105 earth and related environmental sciences MESH: Humans business.industry Public Health Environmental and Occupational Health Case-control study Prostatic Neoplasms MESH: Adult Environmental Exposure medicine.disease MESH: Male Logistic Models Case-Control Studies MESH: Prostatic Neoplasms business |
| Zdroj: | Occupational and Environmental Medicine Occupational and Environmental Medicine, BMJ Publishing Group, 2013, 70 (7), pp.511-8. ⟨10.1136/oemed-2012-101211⟩ |
| ISSN: | 1470-7926 1351-0711 |
| DOI: | 10.1136/oemed-2012-101211 |
| Popis: | Objectives There is a paucity of information on environmental risk factors for prostate cancer. We conducted a case–control study in Montreal to estimate associations with exposure to ground-level nitrogen dioxide (NO 2 ), a marker for traffic-related air pollution. Methods Cases were 803 men with incident prostate cancer, ≤75 years of age, and diagnosed across all French hospitals in Montreal. Concurrently, 969 controls were drawn from electoral lists of French-speaking individuals residing in the same electoral districts as the cases and frequency-matched by age. Concentrations of NO 2 were measured across Montreal in 2005–2006. We developed a land use regression model to predict concentrations of NO 2 across Montreal for 2006. These estimates were back-extrapolated to 1996. Estimates were linked to residential addresses at the time of diagnosis or interview. Unconditional logistic regression was used, adjusting for potential confounding variables. Results For each increase of 5 parts per billion of NO 2 , as estimated from the original land use regression model in 2006, the OR 5ppb adjusted for personal factors was 1.44 (95% CI 1.21 to 1.73). Adding in contextual factors attenuated the OR 5ppb to 1.27 (95% CI 1.03 to 1.58). One method for back-extrapolating concentrations of NO 2 to 1996 (about 10 years before the index date) gave the following OR 5ppb : 1.41 (95% CI 1.24 to 1.62) when personal factors were included, and 1.30 (95% CI 1.11 to 1.52) when contextual factors were added. Conclusions Exposure to ambient concentrations of NO 2 at the current address was associated with an increased risk of prostate cancer. This novel finding requires replication. |
| Databáze: | OpenAIRE |
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