Fetal cerebral hemodynamic in gestational diabetic versus normal pregnancies: a Doppler velocimetry of middle cerebral and umbilical arteries
| Autor: | Mansoureh Shabani Zanjani, Sareh Askari, Seyed-Amir Pooya Alemzadeh, Seyed-Mohammad Fereshtehnejad, Roya Nasirzadeh, Ladan Yoonesi Asl |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Middle Cerebral Artery medicine.medical_specialty Adolescent endocrine system diseases Hemodynamics Gestational Age Statistics Nonparametric Umbilical Arteries Young Adult Pregnancy medicine.artery Diabetes mellitus medicine Humans Fetus business.industry Obstetrics Age Factors Gestational age Ultrasonography Doppler Umbilical artery General Medicine Glucose Tolerance Test Middle Aged medicine.disease Gestational diabetes Diabetes Gestational Cross-Sectional Studies Middle cerebral artery Female Neurology (clinical) business Blood Flow Velocity |
| Zdroj: | Acta Neurologica Belgica. 114:15-23 |
| ISSN: | 2240-2993 0300-9009 2010-2011 |
| DOI: | 10.1007/s13760-013-0221-7 |
| Popis: | Gestational diabetes mellitus (GDM) is one of the most common complications in pregnancies. Evaluating other conditions, including intra uterine growth restriction and pre-eclampsia, some studies have shown significant changes in blood flow velocity of fetal middle cerebral artery (MCA). Our study is one of the few that has aimed to assess the effects of GDM on Doppler parameters of the fetal MCA and umbilical artery (UA) and to compare with normal pregnancies. This cross-sectional study was performed on 66 pregnant women, including 33 women with GDM and the others without it, in Akbar-Abadi University Hospital in Tehran, Iran during 2010-2011. Peak systolic and diastolic velocities, pulsatility index (PI), resistance index (RI) and systolic diastolic ratio (SD) were recorded in UA as well as both right and left fetal MCAs for every recruited pregnant women by means of Doppler ultrasonography. The mean gestational age at the time of examination was 34.45 (SD = 2.62) weeks in GDM group. Although all of the measured Doppler parameters had higher values in GDM pregnancies, the differences were not significant between two groups of study; except for the left fetal MCA-PI, which was significantly higher in GDM group [2.07 (SD = 0.07) vs. 1.85 (SD = 0.74), P = 0.03]. Our results show that gestational diabetes may contribute to an elevated PI in the fetal MCA. Although there is not yet strong proof for the effect of GDM on the fetal brain hemodynamics, the significant higher MCA-PI warrants more attention towards better controlling of the hyperglycemia during pregnancy. |
| Databáze: | OpenAIRE |
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