Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy

Autor:	José Luis Márquez, Eladio Mancilla-Solorza, Kaio Fernando Vitzel, Gabriel Nasri Marzuca-Nassr
Rok vydání:	2018
Předmět:	Aging Chemistry Muscle disuse atrophy Sarcomere macromolecular substances Anatomy Hindlimb Suspension Hindlimb suspension Muscle atrophy Desmin medicine Intermediate filaments medicine.symptom Intermediate filament
Zdroj:	International Journal of Morphology v.36 n.2 2018 SciELO Chile CONICYT Chile instacron:CONICYT
ISSN:	0717-9502
DOI:	10.4067/s0717-95022018000200576
Popis:	SUMMARY: Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Desmin protein contributes to maintenance of cell integrity, efficient transmission of force and mechanochemical signaling within the myocyte. Because of this, desmin protein has constantly been a focus of research that investigates its alterations associated to damage and muscle atrophy under different conditions. The purpose of the following literature review is to describe the basic concepts of muscle ultrastructure, emphasizing the desmin protein role under conditions of muscle disuse atrophy and aging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376431062a520a852bdbb4ec2f3538cd https://doi.org/10.4067/s0717-95022018000200576 Zobrazit plný text záznamu Plný text ve formátu PDF