Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis
| Autor: | H. Satoh, Yukio Sato, A. Oda, Eiichi Kodama, Reiji Kasukawa, Tomoe Nishimaki, Makiko Miyata, H. Nomaguchi |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Antibodies Arthritis Rheumatoid Rheumatology Internal medicine Synovitis Heat shock protein Synovial Fluid medicine Humans Mycobacterium leprae Heat-Shock Proteins biology business.industry General Medicine Middle Aged medicine.disease biology.organism_classification Immunoglobulin Classes Immunoglobulin A Molecular Weight Titer Rheumatoid arthritis Immunology biology.protein Female Antibody business |
| Zdroj: | Clinical rheumatology. 13(2) |
| ISSN: | 0770-3198 |
| Popis: | Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for sera or indexes (OD values divided by amounts of immunoglobulin in each class) for synovial fluids and for their paired sera. Indexes of anti-hsp antibody were higher in synovial fluids than those in sera at 15/18 for IgG, 17/18 for IgA and 16/18 for IgM class. These results suggest the participation of anti-hsp antibodies to synovitis in RA. |
| Databáze: | OpenAIRE |
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