Ethanolamine bacterial microcompartments: from structure, function studies to bioengineering applications
| Autor: | Anaya R Pokhrel, Claudia Schmidt-Dannert, Sun young Kang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Organelles 0303 health sciences Bacteria 030306 microbiology Structure function Bioengineering Protein engineering Computational biology Biology Microbiology 03 medical and health sciences Synthetic biology chemistry.chemical_compound Infectious Diseases Ethanolamine chemistry Bacterial Proteins Bacterial microcompartment Organelle Functional studies Function (biology) 030304 developmental biology |
| Zdroj: | Current opinion in microbiology. 62 |
| ISSN: | 1879-0364 |
| Popis: | Two decades of structural and functional studies have revealed functions, structures and diversity of bacterial microcompartments. The protein-based organelles encapsulate diverse metabolic pathways in semipermeable, icosahedral or pseudo-icosahedral shells. One of the first discovered and characterized microcompartments are those involved in ethanolamine degradation. This review will summarize their function and assembly along with shared and unique characteristics with other microcompartment types. The modularity and self-assembling properties of their shell proteins make them valuable targets for bioengineering. Advances and prospects for shell protein engineering in vivo and in vitro for synthetic biology and biotechnology applications will be discussed. |
| Databáze: | OpenAIRE |
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