Metabarcoding analysis of gut microbiota of healthy individuals reveals impact of probiotic and maltodextrin consumption
| Autor: | Giovanna E. Felis, Mirta Fiorio, Angela Amoruso, Marco Pane, Matteo Calgaro, M Pandolfo, Ilaria Larini, Nicola Vitulo, Angela Marotta, A. Del Casale, Elisa Salvetti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
lactobacilli
Adult 0301 basic medicine Microbiology (medical) Bifidobacterium longum maltodextrin Biology Gut flora Placebo digestive system Microbiology law.invention Cohort Studies Feces Young Adult 03 medical and health sciences chemistry.chemical_compound Probiotic fluids and secretions 0302 clinical medicine Polysaccharides law Lactobacillus Humans Food science Bifidobacterium metabarcoding analysis gut microbiota Bacteria Probiotics food and beverages Maltodextrin biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology chemistry Cohort Female 030217 neurology & neurosurgery |
| Zdroj: | Beneficial Microbes. 12:121-136 |
| ISSN: | 1876-2891 1876-2883 |
| DOI: | 10.3920/bm2020.0137 |
| Popis: | In a previously published double-blind, placebo-controlled study, we showed that probiotics intake exerted a positive effect on sleep quality and a general improvement across time in different aspects of the profile of mood state, like sadness, anger, and fatigue in 33 healthy individuals. The present work investigates the impact of the probiotic product, constituted of Limosilactobacillus fermentum LF16, Lacticaseibacillus rhamnosus LR06, Lactiplantibacillus plantarum LP01 (all former members of Lactobacillus genus), and Bifidobacterium longum 04, on the gut microbiota composition of the same cohort through a metabarcoding analysis. Both the placebo and probiotic treatments had a significant impact on the microbiota composition. Statistical analysis showed that the microbiota of the individuals could be clustered into three groups, or bacteriotypes, at the baseline, and, inherently, bacterial compositions were linked to different responses to probiotic and placebo intakes. Interestingly, L. rhamnosus and L. fermentum were retrieved in the probiotic-treated cohort, while a bifidogenic effect of maltodextrin, used as placebo, was observed. The present study shed light on the importance of defining bacteriotypes to assess the impact of interventions on the gut microbiota and allowed to reveal microbial components which could be related to positive effects (i.e. sleep quality improvement) to be verified in further studies. |
| Databáze: | OpenAIRE |
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