Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity
| Autor: | Jaime Bermejo, Samira Benyahia, Francisco León, Samir Benayache, Fadila Benayache, José Quintana, Juan C. Hernández, Francisco Estévez, Matias Lopez |
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| Rok vydání: | 2005 |
| Předmět: |
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Molecular Stereochemistry Eucalyptus cladocalyx HL-60 Cells Plant Science Horticulture DEPT Biochemistry Terpene chemistry.chemical_compound Triterpene Ursolic acid Humans Molecular Biology chemistry.chemical_classification Eucalyptus Dose-Response Relationship Drug Molecular Structure biology General Medicine Carbon-13 NMR biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Plant Leaves chemistry Proton NMR Pentacyclic Triterpenes Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Phytochemistry. 66:627-632 |
| ISSN: | 0031-9422 |
| Popis: | A formylated triterpene named cladocalol has been isolated from the leaves of Eucalyptus cladocalyx, together with ursulolactone acetate, ursolic acid, 3β-acetate-12,20(29)-lupadien-28-oic acid, β-sitosterol and the known flavonoid eucalyptine. Their structures were mainly established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H–1H COSY, HSQC, HMBC) and mass spectroscopy as well as by X-ray crystallographic analysis. In this paper, we report on the cytotoxic effect induced by cladocalol and its derivatives on the myeloid leukemia cell line HL-60. |
| Databáze: | OpenAIRE |
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